{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T13:38:11Z","timestamp":1789738691035,"version":"4.0.1"},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,6,23]],"date-time":"2015-06-23T00:00:00Z","timestamp":1435017600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01DC010367"],"award-info":[{"award-number":["R01DC010367"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:sec>\n                    <jats:title>Background and purpose<\/jats:title>\n                    <jats:p>\n                      A subset of patients with Alzheimer's disease (\n                      <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>\n                      ) present with early and prominent language impairment (aphasic\n                      <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>\n                      ). Our previous study demonstrated an association between global \u03b2\u2010amyloid burden measured on [\n                      <jats:sup>11<\/jats:sup>\n                      C] Pittsburgh compound B (PiB) positron emission tomography and general cognitive impairment, but not with aphasia, in such subjects. As a follow\u2010up, whether there is any association between regional \u03b2\u2010amyloid burden, atrophy on magnetic resonance imaging (\n                      <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>\n                      ) and global cognitive impairment, aphasia or other cognitive and functional impairment in aphasic\n                      <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>\n                      is assessed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Forty\u2010four aphasic\n                      <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>\n                      subjects who underwent PiB scanning and volumetric\n                      <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>\n                      and were determined to be positive for \u03b2\u2010amyloid deposition were analyzed. All had completed detailed neurological, neuropsychological and language batteries. Spearman's rank\u2010order correlation was utilized to assess for associations.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Greater visuospatial impairment was associated with increased \u03b2\u2010amyloid burden in the primary visual cortex (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.001). Although there were many trends for associations between neurocognitive and language deficits and regional \u03b2\u2010amyloid burden, there were no strong associations that survived correction for multiple comparisons. However, neurocognitive and language impairment in these subjects strongly correlated with the degree of left lateral temporal and inferior parietal atrophy (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.004).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      The findings from this study suggest a close relation between the severity of regional atrophy and cognitive and language impairment, but argue against a strong association between regional \u03b2\u2010amyloid burden and such deficits in aphasic\n                      <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>\n                      subjects. Hence, other pathological factors may be driving the previously identified association between global \u03b2\u2010amyloid deposition and general cognitive impairment in aphasic\n                      <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ene.12761","type":"journal-article","created":{"date-parts":[[2015,6,23]],"date-time":"2015-06-23T03:17:30Z","timestamp":1435029450000},"page":"313-319","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Regional \u03b2\u2010amyloid burden does not correlate with cognitive or language deficits in Alzheimer's disease presenting as aphasia"],"prefix":"10.1111","volume":"23","author":[{"given":"Y.","family":"Jung","sequence":"first","affiliation":[{"name":"Department of Neurology Mayo Clinic Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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