{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T21:07:36Z","timestamp":1792098456497,"version":"4.4.0"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,7,31]],"date-time":"2015-07-31T00:00:00Z","timestamp":1438300800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>Reports on the safety and efficacy of intraventricularly administered (<jats:styled-content style=\"fixed-case\">IVT<\/jats:styled-content>) colistin for the treatment of <jats:italic>Acinetobacter\u00a0baumannii<\/jats:italic> ventriculomeningitis in adults are limited and no comparative studies of <jats:styled-content style=\"fixed-case\">IVT<\/jats:styled-content> colistin versus intravenous (<jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content>) therapy alone have been published. This study compared outcomes of patients with postneurosurgical ventriculomeningitis caused by extensively drug\u2010resistant <jats:italic>A.\u00a0baumannii<\/jats:italic> treated with <jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content> colistin or <jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content> plus <jats:styled-content style=\"fixed-case\">IVT<\/jats:styled-content> colistin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In an 11\u2010year period, information on 18 consecutive patients with extensively drug\u2010resistant <jats:italic>A.\u00a0baumannii<\/jats:italic> ventriculomeningitis was collected. Infection was defined on the basis of (i) isolation of <jats:italic>A.\u00a0baumannii<\/jats:italic> from the cerebrospinal fluid (<jats:styled-content style=\"fixed-case\">CSF<\/jats:styled-content>); (ii) laboratory evidence of <jats:styled-content style=\"fixed-case\">CSF<\/jats:styled-content> infection; (iii) signs\/symptoms of central nervous system (CNS) infection. Patients were divided into group 1 (nine patients, <jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content> colistin alone) and group 2 (nine patients, <jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content> plus <jats:styled-content style=\"fixed-case\">IVT<\/jats:styled-content> colistin).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Cerebrospinal fluid sterilization was documented for 12 of 18 patients (66.6%). The <jats:styled-content style=\"fixed-case\">CSF<\/jats:styled-content> sterilization rate was 33.3% in group 1 and 100% in group 2 (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.009). The mean time to <jats:styled-content style=\"fixed-case\">CSF<\/jats:styled-content> sterilization was 21\u00a0days (range 8\u201348). Five patients died due to <jats:italic>A.\u00a0baumannii <\/jats:italic><jats:styled-content style=\"fixed-case\">CNS<\/jats:styled-content> infection (all in group 1), and five deaths were unrelated to <jats:italic>A.\u00a0baumannii<\/jats:italic> ventriculomeningitis. Intensive care unit mean length of stay was shorter in group 2 (20.7 vs. 41.6\u00a0days, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.046). Crude relative risk ratio of cumulative incidence of persistent <jats:styled-content style=\"fixed-case\">CNS<\/jats:styled-content> infection in group 1 versus group 2 was 13. No cases of chemical meningitis due to intrathecal colistin administration were encountered.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Intraventricular colistin administration is much more effective than IV therapy alone and does not seem to add further toxicity.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.12789","type":"journal-article","created":{"date-parts":[[2015,7,31]],"date-time":"2015-07-31T06:48:48Z","timestamp":1438325328000},"page":"68-75","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":56,"title":["Intraventricular versus intravenous colistin for the treatment of extensively drug resistant <i>Acinetobacter baumannii<\/i> meningitis"],"prefix":"10.1111","volume":"23","author":[{"given":"P.","family":"De Bonis","sequence":"first","affiliation":[{"name":"Neurosurgery Catholic University School of Medicine Rome Italy"},{"name":"Neurosurgery University Hospital S. Anna Ferrara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5874-7340","authenticated-orcid":false,"given":"G.","family":"Lofrese","sequence":"additional","affiliation":[{"name":"Neurosurgery Catholic University School of Medicine Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Scoppettuolo","sequence":"additional","affiliation":[{"name":"Infectious Diseases Catholic University School of Medicine Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Spanu","sequence":"additional","affiliation":[{"name":"Microbiology Catholic University School of Medicine Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Cultrera","sequence":"additional","affiliation":[{"name":"Infectious Diseases University Hospital S. Anna Ferrara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Labonia","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Transfusion Medicine Hospital for Research and Care Casa Sollievo della Sofferenza San Giovanni Rotondo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. A.","family":"Cavallo","sequence":"additional","affiliation":[{"name":"Neurosurgery University Hospital S. Anna Ferrara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Mangiola","sequence":"additional","affiliation":[{"name":"Neurosurgery Catholic University School of Medicine Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Anile","sequence":"additional","affiliation":[{"name":"Neurosurgery Catholic University School of Medicine Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Pompucci","sequence":"additional","affiliation":[{"name":"Neurosurgery Catholic University School of Medicine Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,7,31]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra070741"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/17.5.843"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00058-07"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkn018"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(09)70055-6"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir197"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2009.06.032"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1179\/146532809X440761"},{"key":"e_1_2_7_10_1","first-page":"957","article-title":"Successful treatment of multidrug\u2010resistant Acinetobacter baumannii ventriculitis with intrathecal and intravenous colistin","volume":"76","author":"Pascale G","year":"2010","journal-title":"Minerva Anestesiol"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1086\/517243"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2005.102.5.0915"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2013.02.006"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2013.02.010"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2009.03019.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00701-009-0382-6"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1086\/324492"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkm181"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s15010-010-0018-z"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.2146\/ajhp100234"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2011.03570.x"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-3019(99)00129-9"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1086\/425368"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciu061"}],"container-title":["European Journal of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fene.12789","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ene.12789","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T05:43:55Z","timestamp":1696225435000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ene.12789"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7,31]]},"references-count":23,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1]]}},"alternative-id":["10.1111\/ene.12789"],"URL":"https:\/\/doi.org\/10.1111\/ene.12789","archive":["Portico"],"relation":{},"ISSN":["1351-5101","1468-1331"],"issn-type":[{"value":"1351-5101","type":"print"},{"value":"1468-1331","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,7,31]]},"assertion":[{"value":"2015-04-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-06-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-07-31","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}