{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T16:41:49Z","timestamp":1790786509022,"version":"4.1.0"},"reference-count":13,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,1,24]],"date-time":"2016-01-24T00:00:00Z","timestamp":1453593600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>Non\u2010motor manifestations are frequently overlooked in degenerative disorders and little is known about their frequency and clinical relevance in SPG4 hereditary spastic paraplegia (SPG4\u2010HSP).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty patients with SPG4\u2010HSP and 30 healthy controls answered\u00a0the Modified Fatigue Impact Scale, Epworth Sleepiness Scale, Brief Pain Inventory and Beck Depression Inventory. Student's <jats:italic>t<\/jats:italic> test was\u00a0used to compare groups and linear regression was used to assess correlations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients had higher fatigue scores than controls (31.0\u00a0\u00b1\u00a016.5 vs. 14.5\u00a0\u00b1\u00a016.0, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.002) as well as pain (3.4\u00a0\u00b1\u00a02.7 vs. 1.0\u00a0\u00b1\u00a01.6, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.001) and depression (12.7\u00a0\u00b1\u00a08.9 vs. 4.4\u00a0\u00b1\u00a03.8, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001, respectively). Fatigue was associated with depression and possibly with disease severity (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.008 and 0.07, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Fatigue, pain and depression are frequent and often severe manifestations in patients with SPG4\u2010HSP.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.12839","type":"journal-article","created":{"date-parts":[[2016,1,25]],"date-time":"2016-01-25T05:18:50Z","timestamp":1453699130000},"page":"408-411","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Non\u2010motor symptoms in patients with hereditary spastic paraplegia caused by SPG4 mutations"],"prefix":"10.1111","volume":"23","author":[{"given":"K. R.","family":"Servelhere","sequence":"first","affiliation":[{"name":"Department of Neurology University of Campinas \u2013 UNICAMP Campinas SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Faber","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Campinas \u2013 UNICAMP Campinas SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. A. M.","family":"Saute","sequence":"additional","affiliation":[{"name":"Medical Genetics Service Federal University of Rio Grande do Sul \u2013 UFRGS Porto Alegre RS Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Moscovich","sequence":"additional","affiliation":[{"name":"Neurology Service Federal University of Paran\u00e1 \u2013 UFPR Curitiba PR Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"D'Abreu","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Campinas \u2013 UNICAMP Campinas SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. B.","family":"Jardim","sequence":"additional","affiliation":[{"name":"Medical Genetics Service Federal University of Rio Grande do Sul \u2013 UFRGS Porto Alegre RS Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. A. G.","family":"Teive","sequence":"additional","affiliation":[{"name":"Neurology Service Federal University of Paran\u00e1 \u2013 UFPR Curitiba PR Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Lopes\u2010Cendes","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics University of Campinas \u2013 UNICAMP Campinas SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"M. C.","family":"Franca","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Campinas \u2013 UNICAMP Campinas SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,1,24]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(08)70258-8"},{"key":"e_1_2_7_3_1","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1590\/0004-282X20130248","article-title":"Clinical features and management of hereditary spastic paraplegia","volume":"3","author":"Faber I","year":"2014","journal-title":"Arq Neuropsiquiatr"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/humu.10105"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/cge.12252"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.64.12.1767"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2013.04.007"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31821043a4"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269215509337186"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0004-282X2007000400024"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1806-37132009000900009"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-010-0844-7"},{"key":"e_1_2_7_13_1","first-page":"453","article-title":"Validation of a Portuguese version of the Beck Depression Inventory and State\u2010Tract Anxiety Inventory in Brazilian subjects","volume":"29","author":"Gorenstein C","year":"1996","journal-title":"Braz J Med Biol Res"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/sc.2009.83"}],"container-title":["European Journal of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fene.12839","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ene.12839","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T15:49:50Z","timestamp":1695570590000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ene.12839"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1,24]]},"references-count":13,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,2]]}},"alternative-id":["10.1111\/ene.12839"],"URL":"https:\/\/doi.org\/10.1111\/ene.12839","archive":["Portico"],"relation":{},"ISSN":["1351-5101","1468-1331"],"issn-type":[{"value":"1351-5101","type":"print"},{"value":"1468-1331","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,1,24]]},"assertion":[{"value":"2015-04-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-08-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-01-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}