{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T21:34:01Z","timestamp":1790026441322,"version":"4.0.1"},"reference-count":20,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,10,25]],"date-time":"2015-10-25T00:00:00Z","timestamp":1445731200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>Our aim was to describe the clinical and electrical features and the long\u2010term evolution of childhood occipital epilepsy of Gastaut (<jats:styled-content style=\"fixed-case\">COE<\/jats:styled-content>\u2010G) in a cohort of patients and to compare long\u2010term prognosis between patients with and without other epileptic syndromes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a retrospective analysis of the long\u2010term outcome of epilepsy in 129 patients with<jats:styled-content style=\"fixed-case\">COE<\/jats:styled-content>\u2010G who were referred to 23 Italian epilepsy centres and one in Austria between 1991 and 2004. Patients were evaluated clinically and with electroencephalograms for 10.1\u221223.0 years. The following clinical characteristics were evaluated: gender, patient age at seizure onset, history of febrile seizures and migraine, family history of epilepsy, duration and seizure manifestations, circadian distribution and frequency of seizures, history of medications including the number of drugs, therapeutic response and final outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Visual hallucinations were the first symptom in 62% and the only manifestation in 38.8% of patients. Patients were subdivided into two groups: group A with isolated<jats:styled-content style=\"fixed-case\">COE<\/jats:styled-content>\u2010G; group B with other epileptic syndromes associated with<jats:styled-content style=\"fixed-case\">COE<\/jats:styled-content>\u2010G. The most significant (<jats:italic>P<\/jats:italic>&lt; 0.05) difference concerned antiepileptic therapy: in group A, 45 children responded to monotherapy; in group B only 15 children responded to monotherapy. At the end of follow\u2010up, the percentage of seizure\u2010free patients was significantly higher in group A than in group B.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Childhood occipital epilepsy of Gastaut has an overall favourable prognosis and a good response to antiepileptic therapy with resolution of seizures and of electroencephalogram abnormalities. The association of typical<jats:styled-content style=\"fixed-case\">COE<\/jats:styled-content>\u2010G symptoms with other types of seizure could be related to a poor epilepsy outcome.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.12840","type":"journal-article","created":{"date-parts":[[2015,10,26]],"date-time":"2015-10-26T03:58:08Z","timestamp":1445831888000},"page":"241-246","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Clinical dissection of childhood occipital epilepsy of Gastaut and prognostic implication"],"prefix":"10.1111","volume":"23","author":[{"given":"A.","family":"Verrotti","sequence":"first","affiliation":[{"name":"Department of Paediatrics University of Perugia Perugia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Laino","sequence":"additional","affiliation":[{"name":"Department of Paediatrics University of Perugia Perugia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V. 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Poma Hospital Mantova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Rauchenzauner","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Medical University Innsbruck Innsbruck Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Cerminara","sequence":"additional","affiliation":[{"name":"Paediatric Neurology Department of Neurosciences Tor Vergata University of Rome Roma Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Di Gennaro","sequence":"additional","affiliation":[{"name":"IRCCS \u2018NEUROMED\u2019 Pozzilli Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Esposito","sequence":"additional","affiliation":[{"name":"Department of Mental Health, Physical and Preventive Medicine Clinic of Child and Adolescent Neuropsychiatry Centre for Childhood Headache Second University of Naples Napoli Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Striano","sequence":"additional","affiliation":[{"name":"Paediatric Neurology and Muscular Diseases Unit Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health University of Genoa \u2018G. 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