{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T02:10:14Z","timestamp":1777428614035,"version":"3.51.4"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,1,23]],"date-time":"2016-01-23T00:00:00Z","timestamp":1453507200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Chang Gung Medical Research Fund"},{"name":"Chang Gung Memorial Hospital, Chiayi, Taiwan","award":["CORPG6D0121"],"award-info":[{"award-number":["CORPG6D0121"]}]},{"name":"Chang Gung Memorial Hospital, Chiayi, Taiwan","award":["CMRPG690073"],"award-info":[{"award-number":["CMRPG690073"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>Recent large series studies have demonstrated that dehydration is common amongst stroke subjects and is associated with poor outcome. However, the effects of hydration status on the development of collaterals have never been discussed. In this study, the hypothesis that hydration status is an important factor for developing collaterals after acute middle cerebral artery (<jats:styled-content style=\"fixed-case\">MCA<\/jats:styled-content>) infarction was tested.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Eighty\u2010seven patients with acute infarction due to occlusion of the <jats:styled-content style=\"fixed-case\">MCA<\/jats:styled-content> were enrolled. Two collateral markers, posterior cerebral artery (<jats:styled-content style=\"fixed-case\">PCA<\/jats:styled-content>) laterality and fluid\u2010attenuated inversion recovery hyperintense vessels (<jats:styled-content style=\"fixed-case\">HV<\/jats:styled-content>s) were assessed from magnetic resonance imaging. Dehydration status was defined by a nitrogen to creatinine ratio \u2267 of 15. The associations between dehydration status and the development of collaterals were estimated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sixty\u2010one of 87 patients (70.1%) were identified as dehydrated. The development of <jats:styled-content style=\"fixed-case\">PCA<\/jats:styled-content> laterality and <jats:styled-content style=\"fixed-case\">HV<\/jats:styled-content>s shows a significant difference between dehydrated and euhydrated patients. A serum nitrogen to creatinine ratio &lt;15, diastolic blood pressure and the presence of a dense <jats:styled-content style=\"fixed-case\">MCA<\/jats:styled-content> on computed tomography were significantly associated with the development of <jats:styled-content style=\"fixed-case\">PCA<\/jats:styled-content> laterality. A serum nitrogen to creatinine ratio &lt;15, the initial National Institutes of Health Stroke Scale score, the presence of a dense <jats:styled-content style=\"fixed-case\">MCA<\/jats:styled-content> and calcifications of the internal carotid artery on computed tomography were significantly associated with the development of <jats:styled-content style=\"fixed-case\">HV<\/jats:styled-content>s. Dehydration remained an independent negative predictor for the development of <jats:styled-content style=\"fixed-case\">PCA<\/jats:styled-content> laterality and <jats:styled-content style=\"fixed-case\">HV<\/jats:styled-content>s in the multivariate analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Hydration status is associated with the development of collateral flow after acute <jats:styled-content style=\"fixed-case\">MCA<\/jats:styled-content> occlusion. This preliminary study provides an imaging clue that hydration status and early hydration therapy could be important for acute stroke management.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.12841","type":"journal-article","created":{"date-parts":[[2016,1,23]],"date-time":"2016-01-23T05:46:59Z","timestamp":1453528019000},"page":"494-500","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Effect of dehydration on the development of collaterals in acute middle cerebral artery occlusion"],"prefix":"10.1111","volume":"23","author":[{"given":"S.\u2010W.","family":"Chang","sequence":"first","affiliation":[{"name":"Department of Diagnostic Radiology Chang Gung Memorial Hospital, Chiayi College of Medicine Chang Gung University Taoyuan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.\u2010C.","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Neurology Chang Gung Memorial 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