{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T21:13:43Z","timestamp":1771967623307,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,10,16]],"date-time":"2015-10-16T00:00:00Z","timestamp":1444953600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100001954","name":"Arizona Kidney Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001954","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002345","name":"Eberhard Karls Universit\u00e4t T\u00fcbingen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002345","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2016,2]]},"abstract":"Background and purpose<\/jats:title>Recently, the CRYSTAL AF<\/jats:styled-content> trial detected paroxysmal atrial fibrillation (AF<\/jats:styled-content>) in 12.4% of patients after cryptogenic ischaemic stroke (IS<\/jats:styled-content>) or cryptogenic transient ischaemic attack (TIA<\/jats:styled-content>) by an insertable cardiac monitor (ICM<\/jats:styled-content>) within 1 year of monitoring. Our aim was (i) to assess if an AF<\/jats:styled-content> risk factor based pre\u2010selection of ICM<\/jats:styled-content> candidates would enhance the rate of AF<\/jats:styled-content> detection and (ii) to determine AF<\/jats:styled-content> risk factors with significant predictive value for AF<\/jats:styled-content> detection.<\/jats:p><\/jats:sec>Methods<\/jats:title>Seventy\u2010five patients with cryptogenic IS<\/jats:styled-content>\/TIA<\/jats:styled-content> were consecutively enrolled if at least one of the following AF<\/jats:styled-content> risk factors was present: a CHA<\/jats:styled-content>2<\/jats:sub>DS<\/jats:styled-content>2<\/jats:sub>\u2010VAS<\/jats:styled-content>c score \u22654, atrial runs, left atrium (LA<\/jats:styled-content>) size >45 mm, left atrial appendage (LAA<\/jats:styled-content>) flow \u22640.2 m\/s, or spontaneous echo contrast in the LAA<\/jats:styled-content>. The electrocardiographic and echocardiographic criteria were chosen as they have been repeatedly reported to predict AF<\/jats:styled-content>; the same applies for four of the six items of the CHA<\/jats:styled-content>2<\/jats:sub>DS<\/jats:styled-content>2<\/jats:sub>\u2010VAS<\/jats:styled-content>c score. The study end\u2010point was the detection of one or more episodes of AF<\/jats:styled-content> (\u22652 min).<\/jats:p><\/jats:sec>Results<\/jats:title>Seventy\u2010four patients underwent implantation of an ICM<\/jats:styled-content>; one patient had AF<\/jats:styled-content> at the date of implantation. After 6 months, AF<\/jats:styled-content> was detected in 21\/75 patients (28%), after 12 months in 25\/75 patients (33.3%). 92% of AF<\/jats:styled-content> episodes were asymptomatic. LA<\/jats:styled-content> size >45 mm and the presence of atrial runs were independently associated with AF<\/jats:styled-content> detection [hazard ratio 3.6 (95% confidence interval 1.6\u20138.4), P<\/jats:italic> = 0.002, and 2.7 (1.2\u20136.7), P<\/jats:italic> = 0.023, respectively].<\/jats:p><\/jats:sec>Conclusions<\/jats:title>The detection rate of AF<\/jats:styled-content> is one\u2010third after 1 year if candidates for an ICM<\/jats:styled-content> after cryptogenic IS<\/jats:styled-content>\/TIA<\/jats:styled-content> are selected by AF<\/jats:styled-content> risk factors. LA<\/jats:styled-content> dilation and atrial runs independently predict AF<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.12843","type":"journal-article","created":{"date-parts":[[2015,10,16]],"date-time":"2015-10-16T05:51:08Z","timestamp":1444974668000},"page":"375-381","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":97,"title":["Insertable cardiac monitors after cryptogenic stroke \u2013 a risk factor based approach to enhance the detection rate for paroxysmal atrial fibrillation"],"prefix":"10.1111","volume":"23","author":[{"given":"S.","family":"Poli","sequence":"first","affiliation":[{"name":"Department of Neurology and Stroke and Hertie Institute for Clinical Brain Research University of T\u00fcbingen T\u00fcbingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Diedler","sequence":"additional","affiliation":[{"name":"Department of Neurology and Stroke and Hertie Institute for Clinical Brain Research University of T\u00fcbingen T\u00fcbingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"H\u00e4rtig","sequence":"additional","affiliation":[{"name":"Department of Neurology and Stroke and Hertie Institute for Clinical Brain Research University of T\u00fcbingen T\u00fcbingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"G\u00f6tz","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Cardiovascular Medicine University of T\u00fcbingen T\u00fcbingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Bauer","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Cardiovascular Medicine University of T\u00fcbingen T\u00fcbingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Sachse","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Cardiovascular Medicine University of T\u00fcbingen T\u00fcbingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Cardiovascular Medicine University of T\u00fcbingen T\u00fcbingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Cardiovascular Medicine University of T\u00fcbingen T\u00fcbingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Stimpfle","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Cardiovascular Medicine University of T\u00fcbingen T\u00fcbingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Duckheim","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Cardiovascular Medicine University of T\u00fcbingen T\u00fcbingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Steeg","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Cardiovascular Medicine University of T\u00fcbingen T\u00fcbingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Eick","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Cardiovascular Medicine University of T\u00fcbingen T\u00fcbingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Schreieck","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Cardiovascular Medicine University of T\u00fcbingen T\u00fcbingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Gawaz","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Cardiovascular Medicine University of T\u00fcbingen T\u00fcbingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"U.","family":"Ziemann","sequence":"additional","affiliation":[{"name":"Department of Neurology and Stroke and Hertie Institute for Clinical Brain Research University of T\u00fcbingen T\u00fcbingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. 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