{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T03:00:05Z","timestamp":1790650805110,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,10,25]],"date-time":"2015-10-25T00:00:00Z","timestamp":1445731200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Neurology Unit staff of San Giovanni Battista Hospital, Turin"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>Subacute and chronic peripheral neuropathies (<jats:styled-content style=\"fixed-case\">PNP<\/jats:styled-content>) have been reported in Parkinson's disease (<jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>) patients treated with levodopa\/carbidopa intestinal gel infusion (<jats:styled-content style=\"fixed-case\">LCIG<\/jats:styled-content>), although several aspects of their incidence and pathogenesis still remain to be clarified. This study main objective is to prospectively report the 2\u2010year incidence of <jats:styled-content style=\"fixed-case\">PNP<\/jats:styled-content> in patients treated with <jats:styled-content style=\"fixed-case\">LCIG<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>The clinical, hematological, nutritional and electrophysiological assessments of 33 consecutive patients have been prospectively collected and evaluated. At baseline (before the start of <jats:styled-content style=\"fixed-case\">LCIG<\/jats:styled-content> therapy), 3\/33 (9%) patients showed symptomatic <jats:styled-content style=\"fixed-case\">PNP<\/jats:styled-content> and 7\/33 (21%) subclinical <jats:styled-content style=\"fixed-case\">PNP<\/jats:styled-content>. During a follow\u2010up of 24.36 \u00b1 12.18 months, 2\/23 patients with normal baseline clinical\u2010electrophysiological assessment developed a subacute <jats:styled-content style=\"fixed-case\">PNP<\/jats:styled-content>, 2\/23 developed a chronic <jats:styled-content style=\"fixed-case\">PNP<\/jats:styled-content> and 7\/23 developed a subclinical <jats:styled-content style=\"fixed-case\">PNP<\/jats:styled-content>. <jats:styled-content style=\"fixed-case\">LCIG<\/jats:styled-content> was immediately halted in the subacute cases, while the infusion therapy was not interrupted in chronic and subclinical forms. All <jats:styled-content style=\"fixed-case\">PNP<\/jats:styled-content> were supplemented with vitamin B1 and B12, showing a clinical improvement and\/or substantial stability at the following evaluations. Higher levodopa\u2010equivalent daily dose (<jats:italic>P<\/jats:italic>: 0.024) and homocysteine levels (<jats:italic>P<\/jats:italic>: 0.041) were found in chronic <jats:styled-content style=\"fixed-case\">PNP<\/jats:styled-content>, while no correlations were observed with vitamin B12, folate and <jats:styled-content style=\"fixed-case\">UPDRS<\/jats:styled-content> values. A trend towards <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> reduction was observed in both <jats:styled-content style=\"fixed-case\">PNP<\/jats:styled-content> and unaffected subjects and one patient developed a symptomatic <jats:styled-content style=\"fixed-case\">PNP<\/jats:styled-content> associated with a relevant weight loss.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Serial clinical\u2010electrophysiological evaluations are mandatory in patients treated with <jats:styled-content style=\"fixed-case\">LCIG<\/jats:styled-content>, given the possible risk of subacute and chronic <jats:styled-content style=\"fixed-case\">PNP<\/jats:styled-content>. No clear causative factors has been recognized in the subacute forms, whilst homocysteine\u2010mediated neurotoxicity seems to underlie the pathogenesis of chronic forms.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.12846","type":"journal-article","created":{"date-parts":[[2015,10,26]],"date-time":"2015-10-26T04:01:18Z","timestamp":1445832078000},"page":"501-509","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":68,"title":["Peripheral neuropathy associated with levodopa\u2013carbidopa intestinal infusion: a long\u2010term prospective assessment"],"prefix":"10.1111","volume":"23","author":[{"given":"A.","family":"Merola","sequence":"first","affiliation":[{"name":"Department of Neuroscience University of Turin Torino Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Romagnolo","sequence":"additional","affiliation":[{"name":"Department of Neuroscience University of Turin Torino 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