{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T12:51:33Z","timestamp":1772887893806,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,10,25]],"date-time":"2015-10-25T00:00:00Z","timestamp":1445731200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100006129","name":"Konung Gustaf V:s och Drottning Victorias Frimurarestiftelse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003252","name":"Lunds Universitet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003252","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>The known monogenic forms of stroke are rare. The aim of this study was to analyze pedigrees of young stroke patients regarding possible monogenic cerebrovascular disease and to evaluate the possibility of genetic stroke in these families. This may contribute to a better understanding of disease mechanism in stroke.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Lund Stroke Register includes consecutive patients with first\u2010ever stroke from a defined geographical area in southern Sweden. Early\u2010onset (\u226455 years) stroke patients were systematically screened with regard to family history (<jats:styled-content style=\"fixed-case\">FH<\/jats:styled-content>x), and families with stroke aggregation were compiled. Participants provided information in a questionnaire on occurrence of stroke or transient ischaemic attack (<jats:styled-content style=\"fixed-case\">TIA<\/jats:styled-content>) in their families. Information on cardiovascular risk factors (<jats:styled-content style=\"fixed-case\">VRF<\/jats:styled-content>s) and clinical stroke subtype was collected. <jats:styled-content style=\"fixed-case\">FH<\/jats:styled-content>x for stroke was considered positive when the patient reported either \u22651 first\u2010degree relative with stroke\/<jats:styled-content style=\"fixed-case\">TIA<\/jats:styled-content>, or no first\u2010degree relative but \u22653 second\u2010 or third\u2010degree relatives with stroke\/<jats:styled-content style=\"fixed-case\">TIA<\/jats:styled-content> in a distribution compatible with monogenic inheritance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 4103 stroke patients registered, 426 (10%) had first\u2010ever stroke at \u226455 years and 338 (79%) of these answered the questionnaire. Of them, 159 (47%) reported a positive <jats:styled-content style=\"fixed-case\">FH<\/jats:styled-content>x. Twenty\u2010eight (18%) of the probands with positive <jats:styled-content style=\"fixed-case\">FH<\/jats:styled-content>x had no known <jats:styled-content style=\"fixed-case\">VRF<\/jats:styled-content>s. Thirty\u2010two families with \u22654 members with stroke were identified. In all these larger families the affected individuals with stroke were present in more than one generation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Aggregation of stroke in families of early\u2010onset stroke patients is not uncommon. Genetic factors with impact on stroke risk, including monogenic causes, need to be evaluated in future stroke studies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.12881","type":"journal-article","created":{"date-parts":[[2015,10,26]],"date-time":"2015-10-26T04:00:21Z","timestamp":1445832021000},"page":"401-407","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Familial aggregation of stroke amongst young patients in Lund Stroke Register"],"prefix":"10.1111","volume":"23","author":[{"given":"A.","family":"Ilinca","sequence":"first","affiliation":[{"name":"Lund University Department of Clinical Sciences Lund, Neurology Lund Sweden"},{"name":"Department of Internal Medicine Landskrona Hospital Landskrona Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"U.","family":"Kristoffersson","sequence":"additional","affiliation":[{"name":"Department of Clinical Genetics Lund University and Regional Laboratories Region Sk\u00e5ne Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Soller","sequence":"additional","affiliation":[{"name":"Department of Clinical Genetics Lund University and Regional Laboratories Region Sk\u00e5ne Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. G.","family":"Lindgren","sequence":"additional","affiliation":[{"name":"Lund University Department of Clinical Sciences Lund, Neurology Lund Sweden"},{"name":"Department of Neurology and Rehabilitation Medicine Sk\u00e5ne University Hospital Lund Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,10,25]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)07492-2"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000107187.84390.AA"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000088668"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/hs1201.099795"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000169944.46025.09"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1159\/000357150"},{"key":"e_1_2_8_8_1","volume-title":"Stroke Genetics","author":"Sharma P","year":"2012"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.5853\/jos.2014.16.3.114"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.107.490896"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000121646.23955.0f"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000252955.17126.6a"},{"key":"e_1_2_8_13_1","volume-title":"Human Molecular Genetics. 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