{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T09:37:59Z","timestamp":1784367479908,"version":"3.55.0"},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,11,22]],"date-time":"2015-11-22T00:00:00Z","timestamp":1448150400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Dutch MS Research Foundation"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>Neuromyelitis optica spectrum disorders (NMOSDs) are a group of rare inflammatory demyelinating disorders of the central nervous system. The identification of specific antibodies directed to aquaporin 4 (AQP4\u2010IgG) led to the distinction from multiple sclerosis. However, up to 25% of the clinically diagnosed NMO patients are seronegative for AQP4\u2010IgG. A subgroup of these patients might be identified by antibodies directed to myelin oligodendrocyte glycoprotein (MOG\u2010IgG). Our objective was to investigate whether the clinical characteristics of these patients differ.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Using a cell\u2010based assay, samples of 61 AQP4\u2010IgG seronegative patients and 41 AQP4\u2010IgG seropositive patients with clinically NMOSD were analysed for the presence of MOG\u2010IgG. Clinical characteristics of the AQP4\u2010IgG, MOG\u2010IgG seropositive and double seronegative NMOSD patients were compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty of the 61 AQP4\u2010IgG seronegative patients tested MOG\u2010IgG seropositive (33%). MOG\u2010IgG seropositive patients were more frequently males in contrast to AQP4\u2010IgG seropositive patients (55% vs. 15%, <jats:italic>P<\/jats:italic> &lt; 0.01) and Caucasians (90% vs. 63%, <jats:italic>P<\/jats:italic> = 0.03). They more frequently presented with coincident optic neuritis and transverse myelitis (40% vs. 12%, <jats:italic>P<\/jats:italic> = 0.02) and had a monophasic disease course (70% vs. 29%, <jats:italic>P<\/jats:italic> &lt; 0.01). AQP4\u2010IgG seropositive patients were 2.4 times more likely to suffer from relapses compared with MOG\u2010IgG seropositive patients (relative risk 2.4, 95% confidence interval 1.2\u20134.7). AQP4\u2010IgG seropositive patients had higher Expanded Disability Status Scale levels at last follow\u2010up (<jats:italic>P<\/jats:italic> &lt; 0.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Antibodies directed to MOG identify a subgroup of AQP4\u2010IgG seronegative NMO patients with generally a favourable monophasic disease course.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.12898","type":"journal-article","created":{"date-parts":[[2015,11,23]],"date-time":"2015-11-23T04:16:53Z","timestamp":1448252213000},"page":"580-587","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":102,"title":["Neuromyelitis optica spectrum disorders: comparison of clinical and magnetic resonance imaging characteristics of AQP4\u2010IgG versus MOG\u2010IgG seropositive cases in the Netherlands"],"prefix":"10.1111","volume":"23","author":[{"given":"E. D.","family":"van Pelt","sequence":"first","affiliation":[{"name":"Department of Neurology MS Centre ErasMS Erasmus MC Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y. Y. M.","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Neurology MS Centre ErasMS Erasmus MC Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I. A.","family":"Ketelslegers","sequence":"additional","affiliation":[{"name":"Department of Neurology MS Centre ErasMS Erasmus MC Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Hamann","sequence":"additional","affiliation":[{"name":"Department of Immunopathology and Blood Coagulation Sanquin Diagnostic Services Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. Q.","family":"Hintzen","sequence":"additional","affiliation":[{"name":"Department of Neurology MS Centre ErasMS Erasmus MC Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,11,22]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(07)70216-8"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2009.178"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)17551-X"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20050304"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/1352458511412995"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-8-184"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2013.5857"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31826aac4e"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000000101"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/1352458514555785"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2014.03.001"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-015-0256-1"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1212\/NXI.0000000000000089"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1212\/NXI.0000000000000040"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2015-007766"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2014.3602"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/1352458514566666"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2013.118"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000001729"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.33.11.1444"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000001367"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.12679"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1212\/NXI.0000000000000062"}],"container-title":["European Journal of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fene.12898","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fene.12898","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ene.12898","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ene.12898","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ene.12898","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T10:26:12Z","timestamp":1694427972000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ene.12898"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11,22]]},"references-count":23,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,3]]}},"alternative-id":["10.1111\/ene.12898"],"URL":"https:\/\/doi.org\/10.1111\/ene.12898","archive":["Portico"],"relation":{},"ISSN":["1351-5101","1468-1331"],"issn-type":[{"value":"1351-5101","type":"print"},{"value":"1468-1331","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,11,22]]},"assertion":[{"value":"2015-07-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-10-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-11-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}