{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T06:33:45Z","timestamp":1790404425713,"version":"4.1.0"},"reference-count":19,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,2,22]],"date-time":"2016-02-22T00:00:00Z","timestamp":1456099200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2016,5]]},"abstract":"Background and purpose<\/jats:title>The full spectrum of causes of convexal subarachnoid hemorrhage (cSAH<\/jats:styled-content>) requires further investigation. Therefore, our objective was to describe the spectrum of clinical and imaging features of patients with non\u2010traumatic cSAH<\/jats:styled-content>.<\/jats:p><\/jats:sec>Methods<\/jats:title>A retrospective observational study of consecutive patients with non\u2010traumatic cSAH<\/jats:styled-content> was performed at a tertiary referral center. The underlying cause of cSAH<\/jats:styled-content> was characterized and clinical and imaging features that predict a specific etiology were identified. The frequency of future cSAH<\/jats:styled-content> or intracerebral hemorrhage (ICH<\/jats:styled-content>) was determined.<\/jats:p><\/jats:sec>Results<\/jats:title>In all, 88 patients [median age 64 years (range 25\u201385)] with non\u2010traumatic cSAH<\/jats:styled-content> were identified. The most common causes were reversible cerebral vasoconstriction syndrome (RCVS<\/jats:styled-content>) (26, 29.5%), cerebral amyloid angiopathy (CAA<\/jats:styled-content>) (23, 26.1%), indeterminate (14, 15.9%) and endocarditis (9, 10.2%). CAA<\/jats:styled-content> patients commonly presented at an older age than RCVS<\/jats:styled-content> patients (75 years versus 51 years, P<\/jats:italic> < 0.0001). Thirteen patients (14.7%) had recurrent cSAH<\/jats:styled-content>, and 12 patients (13.6%) had a subsequent ICH<\/jats:styled-content>. However, the risk was high amongst those with CAA<\/jats:styled-content> compared to those caused by RCVS<\/jats:styled-content>, with recurrent cSAH<\/jats:styled-content> in 39.1% and subsequent lobar ICH<\/jats:styled-content> in 43.5% of CAA cases.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Our study demonstrates the clinical diversity of cSAH<\/jats:styled-content>. Older age, sensorimotor dysfunction and stereotyped spells suggest CAA<\/jats:styled-content> as the underlying cause. Younger age and thunderclap headache predict RCVS<\/jats:styled-content>. Yet, various other causes also need to be considered in the differential diagnosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.12926","type":"journal-article","created":{"date-parts":[[2016,2,25]],"date-time":"2016-02-25T04:55:52Z","timestamp":1456376152000},"page":"839-846","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Distinguishing clinical and radiological features of non\u2010traumatic convexal subarachnoid hemorrhage"],"prefix":"10.1111","volume":"23","author":[{"given":"J.","family":"Graff\u2010Radford","sequence":"first","affiliation":[{"name":"Department of Neurology Mayo Clinic Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. E.","family":"Fugate","sequence":"additional","affiliation":[{"name":"Department of Neurology Mayo Clinic Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Klaas","sequence":"additional","affiliation":[{"name":"Department of Neurology Mayo Clinic Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. D.","family":"Flemming","sequence":"additional","affiliation":[{"name":"Department of Neurology Mayo Clinic Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. D.","family":"Brown","sequence":"additional","affiliation":[{"name":"Department of Neurology Mayo Clinic Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. A.","family":"Rabinstein","sequence":"additional","affiliation":[{"name":"Department of Neurology Mayo Clinic Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,2,22]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/124.2.249"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.113.004298"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181d55efa"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.111.621847"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.56.4.537"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.109.554378"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(12)70135-7"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2011.68"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000353676"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1159\/000339685"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/head.12197"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1159\/000381223"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/jon.12188"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2015.25"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000345666.83318.03"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181dad605"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2010.03221.x"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-009-0106-0"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2013.12.046"}],"container-title":["European Journal of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fene.12926","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ene.12926","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T19:40:57Z","timestamp":1695498057000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ene.12926"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2,22]]},"references-count":19,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2016,5]]}},"alternative-id":["10.1111\/ene.12926"],"URL":"https:\/\/doi.org\/10.1111\/ene.12926","archive":["Portico"],"relation":{},"ISSN":["1351-5101","1468-1331"],"issn-type":[{"value":"1351-5101","type":"print"},{"value":"1468-1331","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,2,22]]},"assertion":[{"value":"2015-08-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-11-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-02-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}