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The risk of <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> was examined in a cohort of patients with adjustment disorders, a diagnosis made in the presence of a severe response to a stressful life event.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Using Danish medical registries, <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> occurrence was examined in a nationwide population\u2010based cohort of patients with adjustment disorder diagnosed between 1995 and 2011. The standardized incidence ratio of <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> was calculated as the ratio of observed to expected cases, stratified by time and potential risk factors, including depression and anxiety.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Our adjustment disorder cohort (67 786 patients) was followed for a median of 8 years (interquartile range 4, 12.6 years). During follow\u2010up, 119 patients developed <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>, versus 64 expected, corresponding to a standardized incidence ratio of 1.84 (95% confidence interval 1.53, 2.20). Consistent results were observed after stratification on potential risk factors, including depression and anxiety.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Adjustment disorder, a diagnosis made in the presence of severe response to stressful life events, was associated with an increased risk of <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.12933","type":"journal-article","created":{"date-parts":[[2016,1,12]],"date-time":"2016-01-12T14:24:57Z","timestamp":1452608697000},"page":"751-756","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Adjustment disorder and risk of Parkinson's disease"],"prefix":"10.1111","volume":"23","author":[{"given":"E.","family":"Svensson","sequence":"first","affiliation":[{"name":"Department of Clinical Epidemiology Aarhus University Hospital Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. K.","family":"Farkas","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology Aarhus University Hospital Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. L.","family":"Gradus","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology Aarhus University Hospital Aarhus Denmark"},{"name":"National Center for PTSD VA Boston Healthcare System Boston MA USA"},{"name":"Departments of Psychiatry and Epidemiology Boston University Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. L.","family":"Lash","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology Aarhus University Hospital Aarhus Denmark"},{"name":"Department of Epidemiology Rollins School of Public Health Emory University Atlanta GA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. 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