{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T12:29:22Z","timestamp":1763036962348,"version":"3.37.3"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,1,20]],"date-time":"2016-01-20T00:00:00Z","timestamp":1453248000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100012266","name":"Norwegian Rheumatism Association","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100012266","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>Migraine is frequent in patients with systemic lupus erythematosus (<jats:styled-content style=\"fixed-case\">SLE<\/jats:styled-content>), but the pathogenesis and pathophysiology are poorly understood. Migraine is assumed to be a consequence of abnormal neuronal excitability. Based on the hypothesis that the threshold for migraine is lower in <jats:styled-content style=\"fixed-case\">SLE<\/jats:styled-content> patients due to cerebral disturbances, whether structural abnormalities of the brain or relevant biomarkers are associated with headaches in <jats:styled-content style=\"fixed-case\">SLE<\/jats:styled-content> was investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Sixty\u2010seven <jats:styled-content style=\"fixed-case\">SLE<\/jats:styled-content> patients and age\u2010 and gender\u2010matched healthy subjects participated. Volumes of grey matter (<jats:styled-content style=\"fixed-case\">GM<\/jats:styled-content>) and white matter (<jats:styled-content style=\"fixed-case\">WM<\/jats:styled-content>) were estimated from cerebral magnetic resonance images with <jats:styled-content style=\"fixed-case\">SPM<\/jats:styled-content>8 software. Anti\u2010<jats:styled-content style=\"fixed-case\">NR<\/jats:styled-content>2 and anti\u2010P antibodies and protein S100B were measured in cerebrospinal fluid.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In regression analyses, larger <jats:styled-content style=\"fixed-case\">GM<\/jats:styled-content> volumes in <jats:styled-content style=\"fixed-case\">SLE<\/jats:styled-content> patients reduced the odds for headache in general [odds ratio (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>) 0.98, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.048] and for migraine in particular (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 0.95, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.004). No localized loss of <jats:styled-content style=\"fixed-case\">GM<\/jats:styled-content> was observed. Larger <jats:styled-content style=\"fixed-case\">WM<\/jats:styled-content> volumes in patients increased the odds for migraine (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 1.04, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.007). These findings could not be confirmed in healthy subjects. Neither anti\u2010<jats:styled-content style=\"fixed-case\">NR<\/jats:styled-content>2 and anti\u2010P antibodies nor S100B were associated with headaches in <jats:styled-content style=\"fixed-case\">SLE<\/jats:styled-content> patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Systemic lupus erythematosus patients with migraine have a diffuse reduction in <jats:styled-content style=\"fixed-case\">GM<\/jats:styled-content> compared to patients without migraine. This finding was not observed in healthy subjects with migraine, and selected biomarkers did not indicate specific pathophysiological processes in the brain. These findings indicate that unknown pathogenic processes are responsible for the increased frequency of migraine in <jats:styled-content style=\"fixed-case\">SLE<\/jats:styled-content> patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.12946","type":"journal-article","created":{"date-parts":[[2016,1,20]],"date-time":"2016-01-20T06:25:20Z","timestamp":1453271120000},"page":"780-786","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Migraine in patients with systemic lupus erythematosus is associated with reduced cerebral grey matter volume but not with measures of glial activation or anti\u2010<scp>NR<\/scp>2 or anti\u2010P antibodies"],"prefix":"10.1111","volume":"23","author":[{"given":"A. B.","family":"Tjensvoll","sequence":"first","affiliation":[{"name":"Department of Neurology Stavanger University Hospital Stavanger Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. 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