{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T16:18:23Z","timestamp":1791389903764,"version":"4.3.3"},"reference-count":32,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,1,25]],"date-time":"2016-01-25T00:00:00Z","timestamp":1453680000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Health Services Research Competitive Research","award":["HSRG\/0035\/2013"],"award-info":[{"award-number":["HSRG\/0035\/2013"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>Non\u2010motor symptoms (<jats:styled-content style=\"fixed-case\">NMS<\/jats:styled-content>s) are common amongst patients with Parkinson's disease (<jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>); however, little is known about their influence on the health\u2010related quality of life (QoL) over a defined follow\u2010up period. The study was aimed to establish the impact of <jats:styled-content style=\"fixed-case\">NMS<\/jats:styled-content>s on the QoL of patients with <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> over a 2\u2010year follow\u2010up period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>A total of 227 newly referred <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> patients were prospectively recruited between 2013 and 2014. The Non\u2010Motor Symptoms Scale was used to evaluate <jats:styled-content style=\"fixed-case\">NMS<\/jats:styled-content>s burden whilst QoL was assessed with the Parkinson's Disease Questionnaire\u201039 items. Motor disabilities were assessed using the Part <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content> (motor) Unified Parkinson's Disease Rating Scale (<jats:styled-content style=\"fixed-case\">UPDRS<\/jats:styled-content>m).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean age was 64.37 (10.18) years; 59.9% were males and a majority (89.0%) were ethnic Chinese. Almost 65% were unemployed and 84.6% had attained no more than secondary level of education. In the univariate analysis, total <jats:styled-content style=\"fixed-case\">NMS<\/jats:styled-content>s burden, age, gender, subsequent visit, Hoehn and Yahr staging, disease duration and <jats:styled-content style=\"fixed-case\">UPDRS<\/jats:styled-content>m score were individually predictive of change in the Parkinson's Disease Questionnaire Summary Index score from baseline to follow\u2010up visit. However, in the multivariate analysis, total <jats:styled-content style=\"fixed-case\">NMS<\/jats:styled-content>s burden significantly predicted the QoL scores whilst motor scores did not. Specifically, <jats:styled-content style=\"fixed-case\">NMS<\/jats:styled-content> domains 2 (sleep\/fatigue), 3 (mood\/apathy) and 5 (attention\/memory) were most significantly predictive of QoL change.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Unlike motor disabilities, <jats:styled-content style=\"fixed-case\">NMS<\/jats:styled-content>s burden, in particular sleep, mood and attention, have a significant impact on the QoL of <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> patients over a 2\u2010year follow\u2010up period.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.12950","type":"journal-article","created":{"date-parts":[[2016,1,25]],"date-time":"2016-01-25T05:32:42Z","timestamp":1453699962000},"page":"854-860","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":200,"title":["The impact of non\u2010motor symptoms on the quality of life of Parkinson's disease patients: a longitudinal study"],"prefix":"10.1111","volume":"23","author":[{"given":"K. 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