{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:18:23Z","timestamp":1791296303091,"version":"4.1.0"},"reference-count":38,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,1,29]],"date-time":"2016-01-29T00:00:00Z","timestamp":1454025600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:sec><jats:label\/><jats:p>Amyotrophic lateral sclerosis (<jats:styled-content style=\"fixed-case\">ALS<\/jats:styled-content>) is the most common adult\u2010onset motor neuron disease. Alongside identification of aetiologies, development of biomarkers is a foremost research priority. Metabolomics is one promising approach that is being utilized in the search for diagnosis and prognosis markers. Our aim is to provide an overview of the principal research in metabolomics applied to <jats:styled-content style=\"fixed-case\">ALS<\/jats:styled-content>. References were identified using PubMed with the terms \u2018metabolomics\u2019 or \u2018metabolomic\u2019 and \u2018<jats:styled-content style=\"fixed-case\">ALS<\/jats:styled-content>\u2019 or \u2018amyotrophic lateral sclerosis\u2019 or \u2018<jats:styled-content style=\"fixed-case\">MND<\/jats:styled-content>\u2019 or \u2018motor neuron disorders\u2019. To date, nine articles have reported metabolomics research in patients and a few additional studies examined disease physiology and drug effects in patients or models. Metabolomics contribute to a better understanding of <jats:styled-content style=\"fixed-case\">ALS<\/jats:styled-content> pathophysiology but, to date, no biomarker has been validated for diagnosis, principally due to the heterogeneity of the disease and the absence of applied standardized methodology for biomarker discovery. A consensus on best metabolomics methodology as well as systematic independent validation will be an important accomplishment on the path to identifying the long\u2010awaited biomarkers for <jats:styled-content style=\"fixed-case\">ALS<\/jats:styled-content> and to improve clinical trial designs.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.12956","type":"journal-article","created":{"date-parts":[[2016,1,29]],"date-time":"2016-01-29T09:29:39Z","timestamp":1454059779000},"page":"447-454","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Metabolomics in amyotrophic lateral sclerosis: how far can it take us?"],"prefix":"10.1111","volume":"23","author":[{"given":"H.","family":"Blasco","sequence":"first","affiliation":[{"name":"Inserm U930 Tours France"},{"name":"Universit\u00e9 Fran\u00e7ois\u2010Rabelais Tours France"},{"name":"Laboratoire de Biochimie et Biologie Mol\u00e9culaire CHRU de Tours Tours France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Patin","sequence":"additional","affiliation":[{"name":"Inserm U930 Tours France"},{"name":"Universit\u00e9 Fran\u00e7ois\u2010Rabelais Tours France"},{"name":"Laboratoire de Biochimie et Biologie Mol\u00e9culaire CHRU de Tours Tours France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Madji Hounoum","sequence":"additional","affiliation":[{"name":"Inserm U930 Tours France"},{"name":"Universit\u00e9 Fran\u00e7ois\u2010Rabelais Tours France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. 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