{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T11:19:30Z","timestamp":1789989570715,"version":"4.0.1"},"reference-count":35,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,2,24]],"date-time":"2016-02-24T00:00:00Z","timestamp":1456272000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007333","name":"Alzheimer\u2019s Disease Neuroimaging Initiative","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007333","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01 AG024904"],"award-info":[{"award-number":["U01 AG024904"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000070","name":"National Institute of Biomedical Imaging and Bioengineering","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000070","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2016,5]]},"abstract":"\n Background and purpose<\/jats:title>\n \n The association of serum uric acid, cerebrospinal fluid (\n CSF<\/jats:styled-content>\n ) biomarkers of Alzheimer's disease (\n AD<\/jats:styled-content>\n ) and longitudinal cognitive decline was evaluated using the\n AD<\/jats:styled-content>\n Neuroimaging Initiative database.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n In 271 healthy subjects, 596 mild cognitive impairment patients and 197\n AD<\/jats:styled-content>\n patients, serum uric acid and\n CSF AD<\/jats:styled-content>\n biomarkers were measured at baseline, and Mini\u2010Mental State Examination and\n AD<\/jats:styled-content>\n Assessment Scale \u2212 Cognitive Subscale (\n ADAS<\/jats:styled-content>\n \u2010cog) were assessed serially (mean duration, 2.9 years). The effect of uric acid on longitudinal cognitive decline was evaluated using linear mixed effect models for Mini\u2010Mental State Examination and\n ADAS<\/jats:styled-content>\n \u2010cog scores in female and male subjects separately, with possible confounders controlled (model 1). To determine the effects of uric acid independent of\n CSF<\/jats:styled-content>\n biomarker (A\u03b2\n 1\u201342<\/jats:sub>\n or tau) and to test whether the detrimental effects of\n CSF<\/jats:styled-content>\n biomarker differ according to uric acid,\n CSF<\/jats:styled-content>\n biomarker and its interaction with uric acid were further included in model 1 (model 2).\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Higher levels of uric acid were associated with slower cognitive decline, particularly in the mild cognitive impairment and dementia subgroups, and more prominently in female subjects. Model 2 with\n CSF<\/jats:styled-content>\n A\u03b2\n 1\u201342<\/jats:sub>\n showed that higher levels of uric acid were associated with a slower cognitive decline and alleviated the detrimental effect of A\u03b2\n 1\u201342<\/jats:sub>\n on cognitive decline. Model 2 with\n CSF<\/jats:styled-content>\n tau showed that higher levels of uric acid alleviated the detrimental effect of tau on cognitive decline in female subjects but not in male subjects.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Higher levels of uric acid had protective effects on longitudinal cognitive decline independent of and interactively with\n CSF AD<\/jats:styled-content>\n biomarkers.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/ene.12969","type":"journal-article","created":{"date-parts":[[2016,2,26]],"date-time":"2016-02-26T03:09:30Z","timestamp":1456456170000},"page":"948-957","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["Does serum uric acid act as a modulator of cerebrospinal fluid Alzheimer's disease biomarker related cognitive decline?"],"prefix":"10.1111","volume":"23","author":[{"given":"B. S.","family":"Ye","sequence":"first","affiliation":[{"name":"Department of Neurology Yonsei University College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. W.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Neurology Yonsei University College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. H.","family":"Ham","sequence":"additional","affiliation":[{"name":"Department of Neurology Yonsei University College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. J.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Neurology Yonsei University College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. 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