{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T05:15:31Z","timestamp":1780550131774,"version":"3.54.1"},"reference-count":31,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,3,28]],"date-time":"2016-03-28T00:00:00Z","timestamp":1459123200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>Dual antiplatelet therapy (<jats:styled-content style=\"fixed-case\">DAPT<\/jats:styled-content>) with aspirin and clopidogrel for 90 days was recommended as the secondary prevention of minor ischaemic strokes or transient ischaemic attacks (<jats:styled-content style=\"fixed-case\">TIA<\/jats:styled-content>s) in 2014. However, whether the duration of 90 days is optimal for each patient remains unclear. Therefore, the efficacy and safety of short\u2010term (\u22643 months) and prolonged (\u22651 year) <jats:styled-content style=\"fixed-case\">DAPT<\/jats:styled-content> after stroke or <jats:styled-content style=\"fixed-case\">TIA<\/jats:styled-content> were assessed via a systematic review and meta\u2010analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The Cochrane Library, Clinical Trials.gov and PubMed were searched up to December 2014 and nine randomized controlled trials were included involving 21 923 patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Short\u2010term <jats:styled-content style=\"fixed-case\">DAPT<\/jats:styled-content> significantly reduced the risk of ischaemic stroke recurrence by 41% and major vascular events by 30%, without increasing the risk of intracranial haemorrhage. Prolonged <jats:styled-content style=\"fixed-case\">DAPT<\/jats:styled-content> reduced the risk of ischaemic stroke recurrence by 12% and major vascular events by 10%. However, the risk of major bleeding and intracranial haemorrhage increased.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Short\u2010term <jats:styled-content style=\"fixed-case\">DAPT<\/jats:styled-content> appears to be superior to prolonged <jats:styled-content style=\"fixed-case\">DAPT<\/jats:styled-content>. However, the difference in efficacy outcome needs to be carefully explained and confirmed by further well\u2010designed randomized controlled trials.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.12982","type":"journal-article","created":{"date-parts":[[2016,3,30]],"date-time":"2016-03-30T00:39:31Z","timestamp":1459298371000},"page":"1051-1057","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Dual antiplatelet therapy after stroke or transient ischaemic attack \u2013 how long to treat? 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