{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T10:46:40Z","timestamp":1790419600421,"version":"4.1.0"},"reference-count":24,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2016,4,20]],"date-time":"2016-04-20T00:00:00Z","timestamp":1461110400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Dutch Epilepsy Fund","award":["10-18"],"award-info":[{"award-number":["10-18"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:sec>\n                    <jats:title>Background and purpose<\/jats:title>\n                    <jats:p>Few studies exist on long\u2010term post\u2010stroke depressive symptoms and anxiety in young adults, although these young patients have a particular interest in their long\u2010term prognosis, given their usually long life expectancy and being in the midst of an active social, working and family life. The aims of this study were to investigate the prevalence of depressive symptoms and anxiety and their association with clinical and demographic variables and with functional outcome after stroke in young adults.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>\n                      Long\u2010term prevalence of depressive symptoms and anxiety was calculated in 511 patients with a transient ischaemic attack or ischaemic stroke, aged 18\u201350 years, using the Hospital Anxiety and Depression scale, compared with 147 controls. Functional outcome was assessed with the modified Rankin Score (\n                      <jats:styled-content style=\"fixed-case\">mRS<\/jats:styled-content>\n                      ) and the Instrumental Activities of Daily Living scale (\n                      <jats:styled-content style=\"fixed-case\">IADL<\/jats:styled-content>\n                      ). 16.8% of patients had depressive symptoms and 23.0% had anxiety, versus 6.1% (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.001) and 12.2% (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.001) in controls. In ischaemic stroke patients, depressive symptoms and anxiety were associated with poor functional outcome (\n                      <jats:styled-content style=\"fixed-case\">mRS<\/jats:styled-content>\n                      &gt; 2 or\n                      <jats:styled-content style=\"fixed-case\">IADL<\/jats:styled-content>\n                      &lt; 8).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Even a decade after stroke at young age, depressive symptoms and anxiety were prevalent and associated with poor functional outcome. Therefore, even in the long term, treating physicians should be aware of the long\u2010term presence of these symptoms as their recognition may be the first step in improving long\u2010term functional independence.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ene.13009","type":"journal-article","created":{"date-parts":[[2016,4,20]],"date-time":"2016-04-20T03:52:50Z","timestamp":1461124370000},"page":"1262-1268","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":67,"title":["Long\u2010term depressive symptoms and anxiety after transient ischaemic attack or ischaemic stroke in young adults"],"prefix":"10.1111","volume":"23","author":[{"given":"N. A. M. M.","family":"Maaijwee","sequence":"first","affiliation":[{"name":"Department of Neurology Donders Institute for Brain Cognition and Behaviour Centre for Neuroscience Radboud University Nijmegen Medical Centre Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Tendolkar","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Donders Institute for Brain Cognition and Behaviour Centre for Neuroscience Radboud University Nijmegen Medical Centre Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. C. A.","family":"Rutten\u2010Jacobs","sequence":"additional","affiliation":[{"name":"Department of Neurology Donders Institute for Brain Cognition and Behaviour Centre for Neuroscience Radboud University Nijmegen Medical Centre Nijmegen The Netherlands"},{"name":"Department of Clinical Neurosciences University of Cambridge Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. M.","family":"Arntz","sequence":"additional","affiliation":[{"name":"Department of Neurology Donders Institute for Brain Cognition and Behaviour Centre for Neuroscience Radboud University Nijmegen Medical Centre Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Schaapsmeerders","sequence":"additional","affiliation":[{"name":"Department of Neurology Donders Institute for Brain Cognition and Behaviour Centre for Neuroscience Radboud University Nijmegen Medical Centre Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. D.","family":"Dorresteijn","sequence":"additional","affiliation":[{"name":"Department of Neurology Medisch Spectrum Twente Enschede The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. C.","family":"Schoonderwaldt","sequence":"additional","affiliation":[{"name":"Department of Neurology Donders Institute for Brain Cognition and Behaviour Centre for Neuroscience Radboud University Nijmegen Medical Centre Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. J.","family":"van Dijk","sequence":"additional","affiliation":[{"name":"Department of Neurology Donders Institute for Brain Cognition and Behaviour Centre for Neuroscience Radboud University Nijmegen Medical Centre Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.\u2010E.","family":"de Leeuw","sequence":"additional","affiliation":[{"name":"Department of Neurology Donders Institute for Brain Cognition and Behaviour Centre for Neuroscience Radboud University Nijmegen Medical Centre Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,4,20]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-1166(199702)12:2<219::AID-GPS581>3.0.CO;2-E"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001033"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181fb44c8"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/gps.2482"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2004.00937.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.25.7.1360"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.12073"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.3109\/13814788.2012.715147"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.111.621490"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.110.604405"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2377-11-109"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.842"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7525-1-29"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.psy.43.5.386"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.57.11.1071"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2007.01590.x"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000436619.25532.f3"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.23953"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.111.000792"},{"key":"e_1_2_7_21_1","volume-title":"Intelligentie en leeftijd: onderzoek bij Nederlanders van twaalf tot zevenenzeventig jaar [Intelligence and age: study with Dutch people from age 12 to 77]","author":"Verhage F","year":"1964"},{"key":"e_1_2_7_22_1","first-page":"879","article-title":"Long\u2010term prognosis of ischemic stroke in young adults","volume":"2011","author":"Varona JF","year":"2010","journal-title":"Stroke Res Treat"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.61.4.369"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.3109\/15622975.2011.562242"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2004.09.031"}],"container-title":["European Journal of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fene.13009","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ene.13009","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T07:57:59Z","timestamp":1695542279000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ene.13009"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4,20]]},"references-count":24,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2016,8]]}},"alternative-id":["10.1111\/ene.13009"],"URL":"https:\/\/doi.org\/10.1111\/ene.13009","archive":["Portico"],"relation":{},"ISSN":["1351-5101","1468-1331"],"issn-type":[{"value":"1351-5101","type":"print"},{"value":"1468-1331","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,4,20]]},"assertion":[{"value":"2015-12-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-03-02","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-04-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}