{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T23:51:47Z","timestamp":1789775507440,"version":"4.0.1"},"reference-count":27,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2016,4,23]],"date-time":"2016-04-23T00:00:00Z","timestamp":1461369600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Shire Human Genetic Therapies to the University of Rostock"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>Acute lesions in patients with transient ischaemic attack (TIA) are important as they are associated with increased risk for recurrence. Characteristics associated with acute lesions in young TIA patients were therefore investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The sifap1 study prospectively recruited a multinational European cohort (<jats:italic>n<\/jats:italic> = 5023) of patients aged 18\u201355 years with acute cerebrovascular event. The detection of acute ischaemic lesions was based on diffusion\u2010weighted imaging (DWI). The frequency of DWI lesions was assessed in 829 TIA patients who met the criteria of symptom duration &lt;24 h and their association with demographic, clinical and imaging variables was analysed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median age was 46 years (interquartile range 40\u201351 years); 45% of the patients were female. In 121 patients (15%) \u22651 acute DWI lesion was detected. In 92 patients, DWI lesions were found in the anterior circulation, mostly located in cortical\u2010subcortical areas (<jats:italic>n<\/jats:italic> = 63). Factors associated with DWI lesions in multiple regression analysis were left hemispheric presenting symptoms [odds ratio (OR) 1.92, 95% confidence interval (CI) 1.27\u22122.91], dysarthria (OR 2.17, 95% CI 1.38\u22123.43) and old brain infarctions on MRI (territories of the middle and posterior cerebral artery: OR 2.43, 95% CI 1.42\u22124.15; OR 2.41, 95% CI 1.02\u22125.69, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In young patients with a clinical TIA 15% demonstrated acute DWI lesions on brain MRI, with an event pattern highly suggestive of an embolic origin. Except for the association with previous infarctions there was no clear clinical predictor for acute ischaemic lesions, which indicates the need to obtain MRI in young individuals with TIA.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.13012","type":"journal-article","created":{"date-parts":[[2016,4,23]],"date-time":"2016-04-23T08:58:28Z","timestamp":1461401908000},"page":"1174-1182","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Frequency and predictors of acute ischaemic lesions on brain magnetic resonance imaging in young patients with a clinical diagnosis of transient ischaemic attack"],"prefix":"10.1111","volume":"23","author":[{"given":"C.","family":"Tanislav","sequence":"first","affiliation":[{"name":"Department of Neurology, Justus Liebig University Giessen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"U.","family":"Grittner","sequence":"additional","affiliation":[{"name":"Department for Biostatistics and Clinical Epidemiology Charit\u00e9\u2010Universit\u00e4tsmedizin Berlin Berlin Germany"},{"name":"Centre for Stroke Research Charit\u00e9\u2010Universit\u00e4tsmedizin Berlin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Fazekas","sequence":"additional","affiliation":[{"name":"Department of Neurology Medical University of Graz Graz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Thijs","sequence":"additional","affiliation":[{"name":"Clinical and Experimental Neurology Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Tatlisumak","sequence":"additional","affiliation":[{"name":"Institute of Neuroscience and Physiology and Department of Neurology University of Gothenburg Gothenburg Sweden"},{"name":"Department of Neurology Helsinki University Central Hospital Helsinki Finland"},{"name":"Institute of Neuroscience and Physiology Sahlgrenska Academy at University of Gothenburg Gothenburg Sweden"},{"name":"Department of Neurology Sahlgrenska University Hospital Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Huber","sequence":"additional","affiliation":[{"name":"Department of Neurology, Klinikum Friedrichshafen Friedrichshafen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"von Sarnowski","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Greifswald Greifswald Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Putaala","sequence":"additional","affiliation":[{"name":"Institute of Neuroscience and Physiology and Department of Neurology University of Gothenburg Gothenburg Sweden"},{"name":"Department of Neurology Helsinki University Central Hospital Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Department of Neurology Medical University of Graz Graz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Kropp","sequence":"additional","affiliation":[{"name":"Institute of Medical Psychology and Medical Sociology University of Rostock Rostock Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Norrving","sequence":"additional","affiliation":[{"name":"Department of Clinical Neuroscience Lund University Hospital Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Martus","sequence":"additional","affiliation":[{"name":"Department for Biostatistics and Clinical Epidemiology Charit\u00e9\u2010Universit\u00e4tsmedizin Berlin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Gramsch","sequence":"additional","affiliation":[{"name":"Department of Neurology, Justus Liebig University Giessen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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