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However, wide inter\u2010individual variability exists in the response to GC<\/jats:styled-content>s.<\/jats:p><\/jats:sec>Methods<\/jats:title>A Chinese cohort of 257 MG<\/jats:styled-content> patients treated with GC<\/jats:styled-content>s was evaluated for the association between 19 single nucleotide polymorphisms in the GR<\/jats:styled-content><\/jats:italic> gene and clinical response to the initial 3 month GC<\/jats:styled-content> therapy. A quantitative MG<\/jats:styled-content> score decreasing by \u22653 units or becoming zero was defined as sensitivity to GC<\/jats:styled-content>s.<\/jats:p><\/jats:sec>Results<\/jats:title>The rs17209237* G allele was less frequent in the GC<\/jats:styled-content> insensitive group compared with the GC<\/jats:styled-content> sensitive group [P<\/jats:italic> = 0.013, odds ratio (OR<\/jats:styled-content>) 0.119]. The rs9324921* A allele was more frequent in the GC<\/jats:styled-content> insensitive group than in the GC<\/jats:styled-content> sensitive group (P<\/jats:italic> = 0.046, OR<\/jats:styled-content> 1.94). Carriers of the rs17209237 G allele were less frequent in the GC<\/jats:styled-content> insensitive group than in the GC<\/jats:styled-content> sensitive group (dominant model, P<\/jats:italic> = 0.009). Carriers of the rs9324921 A allele were more frequent in the GC<\/jats:styled-content> insensitive group than in the GC<\/jats:styled-content> sensitive group (dominant model, P<\/jats:italic> = 0.037). Multivariate logistic regression revealed that the rs17209237 G allele carrier (P<\/jats:italic> = 0.037, OR<\/jats:styled-content> 0.12) and disease duration before GC<\/jats:styled-content> treatment (P<\/jats:italic> = 0.011, OR<\/jats:styled-content> 3.45) were independent factors that contributed to GC<\/jats:styled-content> efficacy.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>rs17209237 in the GR<\/jats:styled-content><\/jats:italic> gene was identified as an independent factor that contributes to GC<\/jats:styled-content> efficacy in MG<\/jats:styled-content> patients. The genetic variations of the GR<\/jats:styled-content><\/jats:italic> gene may play a role in predicting response to GC<\/jats:styled-content> treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.13040","type":"journal-article","created":{"date-parts":[[2016,5,17]],"date-time":"2016-05-17T11:52:56Z","timestamp":1463485976000},"page":"1372-1379","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["GR<\/scp><\/i> gene polymorphism is associated with inter\u2010subject variability in response to glucocorticoids in patients with myasthenia gravis"],"prefix":"10.1111","volume":"23","author":[{"given":"Y.","family":"Xie","sequence":"first","affiliation":[{"name":"Department of Neurology Beijing Friendship Hospital Capital Medical University Beijing China"},{"name":"Department of Neurology George Washington University Washington DC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Meng","sequence":"additional","affiliation":[{"name":"Department of Pathology Peking Union Medical College Hospital Chinese Academy of Medical Science Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.\u2010F.","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurology Qilu Hospital of Shandong University Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Neurology Affiliated Hospital of Qingdao University Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Sun","sequence":"additional","affiliation":[{"name":"Key Laboratory of Geriatrics Beijing Hospital and Beijing Institute of Geriatrics, Ministry of Health Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X.","family":"Zhu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Geriatrics Beijing Hospital and Beijing Institute of Geriatrics, Ministry of Health Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.\u2010X.","family":"Yue","sequence":"additional","affiliation":[{"name":"Department of Neurology Qilu Hospital of Shandong University Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X.","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Neurology Affiliated Hospital of Qingdao University Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology Beijing Friendship Hospital Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurology Beijing Friendship Hospital Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. 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