{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T01:33:52Z","timestamp":1792892032003,"version":"4.5.0"},"reference-count":66,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2016,6,27]],"date-time":"2016-06-27T00:00:00Z","timestamp":1466985600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000055","name":"National Institute on Deafness and Other Communication Disorders","doi-asserted-by":"publisher","award":["R01DC01805"],"award-info":[{"award-number":["R01DC01805"]}],"id":[{"id":"10.13039\/100000055","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>Spasmodic dysphonia (<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>), or laryngeal dystonia, is a task\u2010specific isolated focal dystonia of unknown causes and pathophysiology. Although functional and structural abnormalities have been described in this disorder, the influence of its different clinical phenotypes and genotypes remains scant, making it difficult to explain <jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content> pathophysiology and to identify potential biomarkers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We used a combination of independent component analysis and linear discriminant analysis of resting\u2010state functional magnetic resonance imaging data to investigate brain organization in different <jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content> phenotypes (abductor versus adductor type) and putative genotypes (familial versus sporadic cases) and to characterize neural markers for genotype\/phenotype categorization.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found abnormal functional connectivity within sensorimotor and frontoparietal networks in patients with <jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content> compared with healthy individuals as well as phenotype\u2010 and genotype\u2010distinct alterations of these networks, involving primary somatosensory, premotor and parietal cortices. The linear discriminant analysis achieved 71% accuracy classifying <jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content> and healthy individuals using connectivity measures in the left inferior parietal and sensorimotor cortices. When categorizing between different forms of <jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>, the combination of measures from the left inferior parietal, premotor and right sensorimotor cortices achieved 81% discriminatory power between familial and sporadic <jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content> cases, whereas the combination of measures from the right superior parietal, primary somatosensory and premotor cortices led to 71% accuracy in the classification of adductor and abductor <jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content> forms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our findings present the first effort to identify and categorize isolated focal dystonia based on its brain functional connectivity profile, which may have a potential impact on the future development of biomarkers for this rare disorder.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.13067","type":"journal-article","created":{"date-parts":[[2016,6,27]],"date-time":"2016-06-27T12:17:18Z","timestamp":1467029838000},"page":"1517-1527","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":61,"title":["Cortical sensorimotor alterations classify clinical phenotype and putative genotype of spasmodic dysphonia"],"prefix":"10.1111","volume":"23","author":[{"given":"G.","family":"Battistella","sequence":"first","affiliation":[{"name":"Department of Neurology Icahn School of Medicine at Mount Sinai New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Fuertinger","sequence":"additional","affiliation":[{"name":"Department of Neurology Icahn School of Medicine at Mount Sinai New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Fleysher","sequence":"additional","affiliation":[{"name":"Department of Radiology Icahn School of Medicine at Mount Sinai New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. J.","family":"Ozelius","sequence":"additional","affiliation":[{"name":"Department of Neurology Massachusetts General Hospital Charlestown MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Simonyan","sequence":"additional","affiliation":[{"name":"Department of Neurology Icahn School of Medicine at Mount Sinai New York NY USA"},{"name":"Department of Otolaryngology  Icahn School of Medicine at Mount Sinai New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,6,27]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2010.03047.x"},{"key":"e_1_2_7_3_1","first-page":"237","article-title":"Laryngeal dystonia (spasmodic dysphonia): observations of 901 patients and treatment with botulinum toxin","volume":"78","author":"Brin MF","year":"1998","journal-title":"Adv Neurol"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1044\/1092-4388(2006\/081)"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000184478.59063.db"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhq023"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhr120"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awm303"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/1545968315591705"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejn.12977"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2016.02.003"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.25527"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1002209"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0407-13.2013"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910340409"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-009-0208-6"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0905267106"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2013-307127"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-013-0671-y"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNO.0b013e31828f69e5"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.21250"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2015.10.016"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2010.11.014"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2015.03.004"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2014.03.074"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0129250"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0115131"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.22842"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0113879"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2014.12.086"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2015.04.027"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5626-10.2011"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4341-13.2014"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2014.03.042"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbv060"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2015.05.051"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2015.7"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-014-0981-8"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2005.02.018"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-45528-0"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1109\/TMI.2003.822821"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2010.03.008"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.25029"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2013.00149"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0811879106"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2005.1634"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/108.3.593"},{"key":"e_1_2_7_48_1","first-page":"245","article-title":"Motor disorders in basal ganglia disease","volume":"2","author":"Marsden CD","year":"1984","journal-title":"Hum Neurobiol"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.34.7.962"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00964.2014"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2113"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2013.12.007"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1177\/1545968315591705"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2011.01.026"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.02.045"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348940010900215"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhp120"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2006.03.005"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2011.07889.x"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2013.08.014"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2006.12.009"},{"key":"e_1_2_7_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clineuro.2007.09.020"},{"key":"e_1_2_7_63_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awr026"},{"key":"e_1_2_7_64_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhn068"},{"key":"e_1_2_7_65_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2496"},{"key":"e_1_2_7_66_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.23775"},{"key":"e_1_2_7_67_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.48.3.218"}],"container-title":["European Journal of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fene.13067","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ene.13067","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ene.13067","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ene.13067","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T18:53:11Z","timestamp":1693335191000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ene.13067"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6,27]]},"references-count":66,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2016,10]]}},"alternative-id":["10.1111\/ene.13067"],"URL":"https:\/\/doi.org\/10.1111\/ene.13067","archive":["Portico"],"relation":{},"ISSN":["1351-5101","1468-1331"],"issn-type":[{"value":"1351-5101","type":"print"},{"value":"1468-1331","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,6,27]]},"assertion":[{"value":"2015-11-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-05-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-06-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}