{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:49:21Z","timestamp":1787014161018,"version":"build-2736575974"},"reference-count":33,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2016,7,18]],"date-time":"2016-07-18T00:00:00Z","timestamp":1468800000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007775","name":"Universidade Cat\u00f3lica de Bras\u00edlia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007775","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2016,10]]},"abstract":"\n Background and purpose<\/jats:title>\n \n Dopamine agonists in Parkinson's disease (\n PD<\/jats:styled-content>\n ) are associated with impulse control disorders (\n ICD<\/jats:styled-content>\n s) and other compulsive behaviours (together called\n ICD<\/jats:styled-content>\n behaviours). The frequency of\n ICD<\/jats:styled-content>\n behaviours reported as adverse events (\n AE<\/jats:styled-content>\n s) in long\u2010term studies of rotigotine transdermal patch in\n PD<\/jats:styled-content>\n was evaluated.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n This was a\n post hoc<\/jats:italic>\n analysis of six open\u2010label extension studies up to 6\u00a0years in duration. Analyses included patients treated with rotigotine for at least 6\u00a0months and administered the modified Minnesota Impulse Disorders Interview.\n ICD<\/jats:styled-content>\n behaviours reported as\n AE<\/jats:styled-content>\n s were identified and categorized.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n For 786 patients, the mean (\u00b1\n SD<\/jats:styled-content>\n ) exposure to rotigotine was 49.4\u00a0\u00b1\u00a017.6\u00a0months. 71 (9.0%) patients reported 106\n ICD AE<\/jats:styled-content>\n s cumulatively. Occurrence was similar across categories: 2.5% patients reported \u2018compulsive sexual behaviour\u2019, 2.3% \u2018buying disorder\u2019, 2.0% \u2018compulsive gambling\u2019, 1.7% \u2018compulsive eating\u2019 and 1.7% \u2018punding behaviour\u2019. Examining at 6\u2010month intervals, the incidence was relatively low during the first 30\u00a0months; it was higher over the next 30\u00a0months, peaking in the 54\u201360\u2010month period. No\n ICD AE<\/jats:styled-content>\n s were serious, and 97% were mild or moderate in intensity. Study discontinuation occurred in seven (9.9%) patients with\n ICD AE<\/jats:styled-content>\n s; these then resolved in five patients. Dose reduction occurred for 23\n AE<\/jats:styled-content>\n s, with the majority (73.9%) resolving.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n In this analysis of >750 patients with\n PD<\/jats:styled-content>\n treated with rotigotine, the frequency of\n ICD<\/jats:styled-content>\n behaviour\n AE<\/jats:styled-content>\n s was 9.0%, with a specific incidence timeline observed. Active surveillance as duration of treatment increases may help early identification and management; once\n ICD<\/jats:styled-content>\n behaviours are present rotigotine dose reduction may be considered.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/ene.13078","type":"journal-article","created":{"date-parts":[[2016,7,18]],"date-time":"2016-07-18T05:36:57Z","timestamp":1468820217000},"page":"1556-1565","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":61,"title":["Impulse control disorder related behaviours during long\u2010term rotigotine treatment: a\n post hoc<\/i>\n analysis"],"prefix":"10.1111","volume":"23","author":[{"given":"A.","family":"Antonini","sequence":"first","affiliation":[{"name":"Parkinson Unit IRCCS Hospital San Camillo Venice Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. 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