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Although several studies have shown an association between ischaemic stroke and ChP, little is known about the relationship between ChP and <jats:styled-content style=\"fixed-case\">LI<\/jats:styled-content>. The study aims to investigate whether ChP is associated with the presence of lacunar stroke.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>An age\u2010 and gender\u2010matched case\u2013control study of 62 cases (subjects diagnosed with <jats:styled-content style=\"fixed-case\">LI<\/jats:styled-content>) and 60 controls is reported. Clinical periodontal measures (probing pocket depth, recession, clinical attachment level, full mouth plaque score and full mouth gingival bleeding on probing score) were assessed, and associated risk factors for periodontitis and lacunar stroke were ascertained by means of a structured questionnaire.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Chronic periodontitis showed a strong association with <jats:styled-content style=\"fixed-case\">LI<\/jats:styled-content> after adjusting for common vascular risk factors (odds ratio 4.20; 95% confidence interval 1.81\u201310.20; <jats:italic>P<\/jats:italic> = 0.001). Likewise, severe ChP and <jats:styled-content style=\"fixed-case\">LI<\/jats:styled-content> also tended to be significantly associated, independent of other vascular covariates (odds ratio 3.53; 95% confidence interval 1.07\u201312.77; <jats:italic>P<\/jats:italic> = 0.04).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Chronic periodontitis was independently associated with the presence of LI after adjusting for well\u2010known vascular risk factors for lacunar stroke. Further observational studies are necessary to investigate the pathophysiological mechanisms that can explain this relationship.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.13080","type":"journal-article","created":{"date-parts":[[2016,7,15]],"date-time":"2016-07-15T05:52:51Z","timestamp":1468561971000},"page":"1572-1579","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Chronic periodontitis is associated with lacunar infarct: a case\u2013control study"],"prefix":"10.1111","volume":"23","author":[{"given":"Y.","family":"Leira","sequence":"first","affiliation":[{"name":"Department of Periodontology School of Dentistry Faculty of Medicine University of Santiago de Compostela Santiago de Compostela Spain"},{"name":"Health Research Institute of Santiago de Compostela (IDIS) University of Santiago de Compostela Santiago de Compostela 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