{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T14:48:41Z","timestamp":1782398921586,"version":"3.54.5"},"reference-count":20,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2016,7,14]],"date-time":"2016-07-14T00:00:00Z","timestamp":1468454400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Ministry of Science and Technological Development of the Republic of Serbia","award":["175083"],"award-info":[{"award-number":["175083"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>The aim was to determine the electrophysiological profile of our cohort of low density lipoprotein receptor related protein 4 (<jats:styled-content style=\"fixed-case\">LRP<\/jats:styled-content>4) positive myasthenia gravis (<jats:styled-content style=\"fixed-case\">MG<\/jats:styled-content>) patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A repetitive nerve stimulation (<jats:styled-content style=\"fixed-case\">RNS<\/jats:styled-content>) test and jitter analysis using a concentric needle electrode were performed in 17 <jats:styled-content style=\"fixed-case\">LRP<\/jats:styled-content>4 positive <jats:styled-content style=\"fixed-case\">MG<\/jats:styled-content> patients. The results were compared to 31 muscle\u2010specific tyrosine kinase (Mu<jats:styled-content style=\"fixed-case\">SK<\/jats:styled-content>) positive and 28 acetylcholine receptor (<jats:styled-content style=\"fixed-case\">AC<\/jats:styled-content>hR) positive <jats:styled-content style=\"fixed-case\">MG<\/jats:styled-content> patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The <jats:styled-content style=\"fixed-case\">RNS<\/jats:styled-content> test was negative in almost all patients belonging to the <jats:styled-content style=\"fixed-case\">LRP<\/jats:styled-content>4\/seronegative and <jats:styled-content style=\"fixed-case\">LRP<\/jats:styled-content>4\/Mu<jats:styled-content style=\"fixed-case\">SK<\/jats:styled-content> groups. It was positive most frequently in the <jats:styled-content style=\"fixed-case\">AC<\/jats:styled-content>hR <jats:styled-content style=\"fixed-case\">MG<\/jats:styled-content> patients, especially those without anti\u2010<jats:styled-content style=\"fixed-case\">LRP<\/jats:styled-content>4 antibodies. The presence of anti\u2010<jats:styled-content style=\"fixed-case\">LRP<\/jats:styled-content>4 antibodies was connected to lower decrement values, whilst the independent presence of anti\u2010<jats:styled-content style=\"fixed-case\">AC<\/jats:styled-content>hR or anti\u2010Mu<jats:styled-content style=\"fixed-case\">SK<\/jats:styled-content> antibodies was connected to higher decrement values. Lowest jitter was recorded in patients with <jats:styled-content style=\"fixed-case\">LRP<\/jats:styled-content>4\/seronegative <jats:styled-content style=\"fixed-case\">MG<\/jats:styled-content>. The highest percentage of pathological jitter analysis test results was present in Mu<jats:styled-content style=\"fixed-case\">SK<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">AC<\/jats:styled-content>hR <jats:styled-content style=\"fixed-case\">MG<\/jats:styled-content> patients. The isolate presence of anti\u2010<jats:styled-content style=\"fixed-case\">LRP<\/jats:styled-content>4 antibodies did not influence the mean consecutive difference values, whilst mean consecutive difference values were higher in the presence of anti\u2010<jats:styled-content style=\"fixed-case\">AC<\/jats:styled-content>hR or anti\u2010Mu<jats:styled-content style=\"fixed-case\">SK<\/jats:styled-content> antibodies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Low density lipoprotein receptor related protein 4 positive patients make a distinct <jats:styled-content style=\"fixed-case\">MG<\/jats:styled-content> subgroup with rarely detected pathological electrophysiological test results. The lack of influence of anti\u2010<jats:styled-content style=\"fixed-case\">LRP<\/jats:styled-content>4 antibodies on the different electrophysiological parameters brings into question the pathogenic role of anti\u2010<jats:styled-content style=\"fixed-case\">LRP<\/jats:styled-content>4 antibodies in <jats:styled-content style=\"fixed-case\">MG<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.13081","type":"journal-article","created":{"date-parts":[[2016,7,14]],"date-time":"2016-07-14T13:44:55Z","timestamp":1468503895000},"page":"1635-1641","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Electrophysiological findings in patients with low density lipoprotein receptor related protein 4 positive myasthenia gravis"],"prefix":"10.1111","volume":"23","author":[{"given":"A. V.","family":"Nikolic","sequence":"first","affiliation":[{"name":"Neurology Clinic Clinical Center of Serbia Belgrade Serbia"},{"name":"Medical Faculty Belgrade University Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. D.","family":"Bojic","sequence":"additional","affiliation":[{"name":"Institute for Medical Statistics Medical Faculty Belgrade University Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V. M.","family":"Rakocevic Stojanovic","sequence":"additional","affiliation":[{"name":"Neurology Clinic Clinical Center of Serbia Belgrade Serbia"},{"name":"Medical Faculty Belgrade University Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I. Z.","family":"Basta","sequence":"additional","affiliation":[{"name":"Neurology Clinic Clinical Center of Serbia Belgrade Serbia"},{"name":"Medical Faculty Belgrade University Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. 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