{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T11:08:37Z","timestamp":1774264117028,"version":"3.50.1"},"reference-count":10,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,9,19]],"date-time":"2016-09-19T00:00:00Z","timestamp":1474243200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:sec><jats:title>\n<jats:bold>Background and purpose<\/jats:bold>\n<\/jats:title><jats:p>To determine the rate of peri\u2010interventional silent brain infarcts after left atrial appendage occlusion (<jats:styled-content style=\"fixed-case\">LAAO<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>\n<jats:bold>Methods<\/jats:bold>\n<\/jats:title><jats:p>In this prospective, uncontrolled single\u2010center pilot study, consecutive patients with atrial fibrillation undergoing <jats:styled-content style=\"fixed-case\">LAAO<\/jats:styled-content> between July 2013 and January 2016 were included. The Amplatzer Cardiac Plug, <jats:styled-content style=\"fixed-case\">WATCHMAN<\/jats:styled-content> or Amulet device was used. A neurological examination and cranial magnetic resonance imaging (<jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>) were performed within 48 h before and after the procedure. <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> was evaluated for new diffusion\u2010weighted imaging (<jats:styled-content style=\"fixed-case\">DWI<\/jats:styled-content>) hyperintensities, cerebral microbleeds (<jats:styled-content style=\"fixed-case\">CMBs<\/jats:styled-content>) and white\u2010matter lesions (<jats:styled-content style=\"fixed-case\">WMLs<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>\n<jats:bold>Results<\/jats:bold>\n<\/jats:title><jats:p>Left atrial appendage occlusion was performed in 21 patients (mean age, 73.2 \u00b1 9.5 years). Main reasons for <jats:styled-content style=\"fixed-case\">LAAO<\/jats:styled-content> were previous intracerebral hemorrhage (<jats:italic>n<\/jats:italic> = 11) and major systemic bleeding (<jats:italic>n<\/jats:italic> = 6). No clinically overt stroke occurred peri\u2010interventionally. After the intervention, one patient had a small cerebellar hyperintensity on <jats:styled-content style=\"fixed-case\">DWI<\/jats:styled-content> (4.8%; 95% confidence interval, 0.0\u201314.3) that was not present on the <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> 1 day before the procedure. Among 11 patients with available <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> just before <jats:styled-content style=\"fixed-case\">LAAO<\/jats:styled-content>, there were no significant changes in the number of <jats:styled-content style=\"fixed-case\">CMB<\/jats:styled-content>s and the severity of <jats:styled-content style=\"fixed-case\">WMLs<\/jats:styled-content> after <jats:styled-content style=\"fixed-case\">LAAO<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>\n<jats:bold>Conclusions<\/jats:bold>\n<\/jats:title><jats:p>This study of peri\u2010interventional <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">LAAO<\/jats:styled-content> suggests a low rate of silent peri\u2010procedural infarcts in this elderly population. Confirmation in larger studies is needed.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.13129","type":"journal-article","created":{"date-parts":[[2016,9,20]],"date-time":"2016-09-20T04:26:46Z","timestamp":1474345606000},"page":"53-57","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Peri\u2010procedural silent cerebral infarcts after left atrial appendage occlusion"],"prefix":"10.1111","volume":"24","author":[{"given":"M.","family":"Laible","sequence":"first","affiliation":[{"name":"Department of Neurology Heidelberg University Hospital Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"M\u00f6hlenbruch","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology Heidelberg University Hospital Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Horstmann","sequence":"additional","affiliation":[{"name":"Department of Neurology Heidelberg University Hospital Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Pfaff","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology Heidelberg University Hospital Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N. A.","family":"Geis","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III Heidelberg University Hospital Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Pleger","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III Heidelberg University Hospital Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Sch\u00fcler","sequence":"additional","affiliation":[{"name":"Institute of Medical Biometry and Informatics University of Heidelberg Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Rizos","sequence":"additional","affiliation":[{"name":"Department of Neurology Heidelberg University Hospital Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Bendszus","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology Heidelberg University Hospital Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Veltkamp","sequence":"additional","affiliation":[{"name":"Department of Neurology Heidelberg University Hospital Heidelberg Germany"},{"name":"Department of Stroke Medicine Imperial College London London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,9,19]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.03.022"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.04.025"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jjcc.2013.02.019"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.004103"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(93)90041-V"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2007.01689.x"},{"key":"e_1_2_6_8_1","first-page":"519","article-title":"Risk of cerebral embolism after interventional closure of symptomatic patent foramen ovale or atrial septal defect: a diffusion\u2010weighted MRI and neuron\u2010specific enolase\u2010based study","volume":"10","author":"Oktay Tureli H","year":"2013","journal-title":"J Invasive Cardiol"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.2012.02420.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/1747493015616637"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.108.526996"}],"container-title":["European Journal of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fene.13129","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fene.13129","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ene.13129","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T07:47:33Z","timestamp":1695541653000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ene.13129"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9,19]]},"references-count":10,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,1]]}},"alternative-id":["10.1111\/ene.13129"],"URL":"https:\/\/doi.org\/10.1111\/ene.13129","archive":["Portico"],"relation":{},"ISSN":["1351-5101","1468-1331"],"issn-type":[{"value":"1351-5101","type":"print"},{"value":"1468-1331","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,9,19]]},"assertion":[{"value":"2016-05-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-08-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-09-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}