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The follow\u2010up data (15D, Mini\u2010Mental State Examination, Beck Depression Inventory, <jats:styled-content style=\"fixed-case\">iNPH<\/jats:styled-content> Grading Scale), frontal cortical biopsy, Charlson Age Comorbidity Index and body mass index of 145 patients diagnosed with <jats:styled-content style=\"fixed-case\">iNPH<\/jats:styled-content> by clinical and radiological examination were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At 1\u2010year follow\u2010up, 63 (43%) patients had experienced a clinically significant improvement in <jats:styled-content style=\"fixed-case\">HRQ<\/jats:styled-content>oL. Multivariate binary logistic regression analysis indicated that the absence of amyloid\u2010\u03b2 and hyperphosphorylated tau pathology in the frontal cortical biopsy (53% vs. 33%; absolute risk difference, 20%; adjusted odds ratio, 2.27; 95% confidence interval, 1.07\u20134.84; <jats:italic>P<\/jats:italic> &lt; 0.05) and lower body mass index (adjusted odds ratio, 0.90, 95% confidence interval, 0.82\u20130.98; <jats:italic>P<\/jats:italic> &lt; 0.05) predicted favorable <jats:styled-content style=\"fixed-case\">HRQ<\/jats:styled-content>oL outcome 1 year after the shunting.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Less than half of the patients with <jats:styled-content style=\"fixed-case\">iNPH<\/jats:styled-content> experienced clinically significant favorable <jats:styled-content style=\"fixed-case\">HRQ<\/jats:styled-content>oL outcome, partly explained by the patient's characteristics and comorbidities. The <jats:styled-content style=\"fixed-case\">HRQ<\/jats:styled-content>oL approach reveals aspects that are important for the patient's well\u2010being, but may also improve the quality of the outcome assessment of cerebrospinal fluid shunting. Study results may help clinicians to estimate which patients will benefit shunt surgery.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.13130","type":"journal-article","created":{"date-parts":[[2016,9,20]],"date-time":"2016-09-20T04:32:47Z","timestamp":1474345967000},"page":"58-66","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Health\u2010related quality\u2010of\u2010life outcome in patients with idiopathic normal\u2010pressure hydrocephalus \u2013 a 1\u2010year follow\u2010up study"],"prefix":"10.1111","volume":"24","author":[{"given":"A.","family":"Junkkari","sequence":"first","affiliation":[{"name":"Neurosurgery of NeuroCenter Kuopio University Hospital and University of Eastern Finland Kuopio Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"H\u00e4yrinen","sequence":"additional","affiliation":[{"name":"Neurosurgery of NeuroCenter Kuopio University Hospital and University of Eastern Finland Kuopio Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Rauramaa","sequence":"additional","affiliation":[{"name":"Department of Pathology Kuopio University Hospital and University of Eastern Finland Kuopio Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Sintonen","sequence":"additional","affiliation":[{"name":"Department of Public Health University of Helsinki Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.","family":"Nerg","sequence":"additional","affiliation":[{"name":"Neurology of NeuroCenter University of Eastern Finland and Kuopio University Hospital Kuopio Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. 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