{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T20:18:27Z","timestamp":1777148307169,"version":"3.51.4"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,10,7]],"date-time":"2016-10-07T00:00:00Z","timestamp":1475798400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000732","name":"UK-India Education and Research Initiative","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000732","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000272","name":"National Institute for Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000765","name":"University College London","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000765","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2017,1]]},"abstract":"Background and purpose<\/jats:title>Twenty\u2010four\u2010hour ambulatory blood pressure and heart rate monitoring (24\u2010h ABPM<\/jats:styled-content>) can provide vital information on circadian blood pressure (BP<\/jats:styled-content>) profiles, which are commonly abnormal in Parkinson's disease with and without autonomic failure (PD<\/jats:styled-content> + AF<\/jats:styled-content> and PD<\/jats:styled-content>) and multiple system atrophy (MSA<\/jats:styled-content>). Twenty\u2010four\u2010hour ABPM<\/jats:styled-content> has not been directly compared between these disorders regarding cardiovascular autonomic function. Our aim was to determine the usefulness of 24\u2010h ABPM<\/jats:styled-content> with diary compared to head\u2010up tilting (HUT<\/jats:styled-content>) in diagnosing orthostatic hypotension (OH<\/jats:styled-content>) in these patients.<\/jats:p><\/jats:sec>Methods<\/jats:title>Seventy\u2010four patients (23 MSA<\/jats:styled-content>, 18 PD<\/jats:styled-content> + AF<\/jats:styled-content>, 33 PD<\/jats:styled-content>) underwent cardiovascular autonomic screening followed by 24\u2010h ABPM<\/jats:styled-content> with diary. Standing tests were included during 24\u2010h ABPM<\/jats:styled-content>. The sensitivity and specificity in detecting OH<\/jats:styled-content> from the 24\u2010h ABPM<\/jats:styled-content> standing test were compared with HUT<\/jats:styled-content>.<\/jats:p><\/jats:sec>Results<\/jats:title>There was no difference in OH<\/jats:styled-content> during HUT<\/jats:styled-content> between MSA<\/jats:styled-content> and PD<\/jats:styled-content> + AF<\/jats:styled-content> (P<\/jats:italic> > 0.05). There was a higher proportion of abnormal BP<\/jats:styled-content> circadian rhythms in MSA<\/jats:styled-content> and PD<\/jats:styled-content> + AF<\/jats:styled-content> compared to PD<\/jats:styled-content> (P<\/jats:italic> < 0.05) but not between MSA<\/jats:styled-content> and PD<\/jats:styled-content> + AF<\/jats:styled-content> (P<\/jats:italic> > 0.05). Patients were divided into groups with OH<\/jats:styled-content> (OH<\/jats:styled-content>+) and without OH<\/jats:styled-content> (OH<\/jats:styled-content>\u2212) on HUT<\/jats:styled-content>. Using the standing test during 24\u2010h ABPM<\/jats:styled-content>, a systolic BP<\/jats:styled-content> fall of >20 mmHg showed a sensitivity and specificity of 82% and 100% (area under the curve 0.91, 95% confidence interval 0.84\u20130.98) in differentiating OH<\/jats:styled-content>+ from OH<\/jats:styled-content>\u2212.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Parkinson's disease with autonomic failure and MSA<\/jats:styled-content> patients had similar circadian BP<\/jats:styled-content> patterns suggesting that autonomic dysfunction influences abnormal BP<\/jats:styled-content> circadian patterns similarly in these disorders. The higher sensitivity and specificity in detecting OH<\/jats:styled-content> using a systolic BP<\/jats:styled-content> fall of >20 mmHg compared to a diastolic BP<\/jats:styled-content> fall of >10 mmHg during the standing test supports its usefulness to assess autonomic function in MSA<\/jats:styled-content> and PD<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.13135","type":"journal-article","created":{"date-parts":[[2016,10,13]],"date-time":"2016-10-13T06:31:12Z","timestamp":1476340272000},"page":"90-97","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Twenty\u2010four\u2010hour ambulatory blood pressure and heart rate profiles in diagnosing orthostatic hypotension in Parkinson's disease and multiple system atrophy"],"prefix":"10.1111","volume":"24","author":[{"given":"E.","family":"Vichayanrat","sequence":"first","affiliation":[{"name":"Autonomic Unit National Hospital for Neurology and Neurosurgery (NHNN) London UK"},{"name":"Autonomic and Neurovascular Medicine Unit Faculty of Medicine Imperial College London at St Mary's Hospital London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. A.","family":"Low","sequence":"additional","affiliation":[{"name":"Autonomic and Neurovascular Medicine Unit Faculty of Medicine Imperial College London at St Mary's Hospital London UK"},{"name":"Research Institute for Sport and Exercise Sciences Liverpool John Moores University Liverpool UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Iodice","sequence":"additional","affiliation":[{"name":"Autonomic Unit National Hospital for Neurology and Neurosurgery (NHNN) London UK"},{"name":"Autonomic and Neurovascular Medicine Unit Faculty of Medicine Imperial College London at St Mary's Hospital London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Stuebner","sequence":"additional","affiliation":[{"name":"Clinic for Neurology and Clinical Neurophysiology Centre of Research in Clinical Medicine (ZFKM) Helios clinic Wuppertal University of Witten\/Herdecke Wuppertal Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6925-6747","authenticated-orcid":false,"given":"E. M.","family":"Hagen","sequence":"additional","affiliation":[{"name":"Autonomic and Neurovascular Medicine Unit Faculty of Medicine Imperial College London at St Mary's Hospital London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. J.","family":"Mathias","sequence":"additional","affiliation":[{"name":"Autonomic Unit National Hospital for Neurology and Neurosurgery (NHNN) London UK"},{"name":"Autonomic and Neurovascular Medicine Unit Faculty of Medicine Imperial College London at St Mary's Hospital London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,10,7]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.111.180653"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(88)92867-X"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000081216.11623.C3"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.22767"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2006.02.020"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01819664"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10286-011-0119-5"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02291236"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.46.5.1470"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/med\/9780198566342.001.0001"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.320.7242.1128"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e328363e964"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000154900.76284.F6"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2013.11.006"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1521-1878(200001)22:1<23::AID-BIES6>3.0.CO;2-Z"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1517\/14728222.12.6.717"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.3109\/07420528.2012.715872"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.1039"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(08)61581-2"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awl109"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-510X(97)00210-4"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.30.5.1062"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.101.23.2710"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10286-014-0229-y"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2013.00049"}],"container-title":["European Journal of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fene.13135","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fene.13135","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ene.13135","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T07:48:53Z","timestamp":1695541733000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ene.13135"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10,7]]},"references-count":25,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,1]]}},"alternative-id":["10.1111\/ene.13135"],"URL":"https:\/\/doi.org\/10.1111\/ene.13135","archive":["Portico"],"relation":{},"ISSN":["1351-5101","1468-1331"],"issn-type":[{"value":"1351-5101","type":"print"},{"value":"1468-1331","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,10,7]]},"assertion":[{"value":"2016-02-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-08-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-10-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}