{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T05:39:13Z","timestamp":1761975553402},"reference-count":48,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,10,18]],"date-time":"2016-10-18T00:00:00Z","timestamp":1476748800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>Amyotrophic lateral sclerosis (ALS), a motor neuron disease, is associated with various cortical symptoms including mild cognitive decline with behavior changes, suggesting the involvement of extra\u2010motor areas in ALS. Our aim was to investigate the specific patterns of brain atrophy in sporadic, impaired ALS patients without commonly known genetic mutations using voxel\u2010based morphometry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>Forty\u2010seven patients with sporadic ALS and 28 age\u2010matched healthy controls were recruited. ALS participants were divided into three groups according to comprehensive neuropsychological testing: pure (ALS\u2010pure), cognitive impairment (ALSci) and behavioral impairment (ALSbi). Quantitative comparison of brain atrophy patterns was performed amongst these three groups using voxel\u2010based analysis. All analyses were adjusted for total intracranial volume, age, sex, disease duration and functional disability score.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The ALSci group exhibited decreased volume in the left cerebellum, fusiform gyrus, optic radiations and corticospinal tracts compared to healthy controls. ALSci patient imaging showed decreased brain volume in the bilateral cerebellum, right putamen gray matter and bilateral superior longitudinal fasciculi white matter compared to pure ALS patients (<jats:italic>P<\/jats:italic> &lt; 0.001 uncorrected, corrected for the entire volume). Compared to healthy controls, ALS\u2010pure and ALSbi groups did not show any significant volume changes in gray and white matter.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These findings also support the hypothesis that ALS pathogenesis has a dual focality of onset (cortex and anterior horn) with contiguous spread outwards. Additionally, neuropsychological features may be an important predictor of progression and survival rates in ALS.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.13163","type":"journal-article","created":{"date-parts":[[2016,10,18]],"date-time":"2016-10-18T05:26:42Z","timestamp":1476768402000},"page":"122-129","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Structural explanation of poor prognosis of amyotrophic lateral sclerosis in the non\u2010demented state"],"prefix":"10.1111","volume":"24","author":[{"given":"H.\u2010J.","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Neurology College of Medicine Hanyang University Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.\u2010I.","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Neurology Busan Paik Hospital Inje University College of Medicine Busan Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"de Leon","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Center for Brain Health NYU School of Medicine New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X.","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology NYU School of Medicine New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.\u2010W.","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Neurology College of Medicine Hanyang University Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.\u2010S.","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Neurology College of Medicine Hanyang University Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Deshpande","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Center for Brain Health NYU School of Medicine New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Buj","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Center for Brain Health NYU School of Medicine New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. H.","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurology College of Medicine Hanyang University Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,10,18]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200105313442207"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-510X(00)00425-1"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000172911.39167.b6"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12031-011-9636-x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.10293"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0007107"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/17482960600947648"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0087163"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/17482960802654364"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tig.2015.03.005"},{"key":"e_1_2_6_12_1","first-page":"96","article-title":"El Escorial World Federation of Neurology criteria for the diagnosis of amyotrophic lateral sclerosis. Subcommittee on Motor Neuron Diseases\/Amyotrophic Lateral Sclerosis of the World Federation of Neurology Research Group on Neuromuscular Diseases and the El Escorial \u2018Clinical limits of amyotrophic lateral sclerosis\u2019 workshop contributors","volume":"124","author":"Brooks BR","year":"1994","journal-title":"J Neurol Sci"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2012.09.004"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2013.11.033"},{"key":"e_1_2_6_15_1","first-page":"149","article-title":"Korean version of amyotrophic lateral sclerosis functional rating scale\u2010revised: a pilot study on the reliability and validity","volume":"25","author":"Kim HY","year":"2007","journal-title":"J Korean Neurol Assoc"},{"key":"e_1_2_6_16_1","volume-title":"Contributions to Neuropsychological Assessment: A Clinical Manual","author":"Benton A","year":"1983"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1076\/jcen.21.1.127.942"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1080\/13803390490515397"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2006.115"},{"key":"e_1_2_6_20_1","volume-title":"Hopkins Verbal Learning Test \u2212 revised: Professional Manual","author":"Brandt J","year":"2001"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1207\/s15324826an0302_8"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.14385\/KSSP.25.2.1"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.43.11.2412-a"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1177\/089198873258818"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000167602.38643.29"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2011.12.003"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.24415"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.20364"},{"key":"e_1_2_6_29_1","first-page":"255","article-title":"Whole\u2010brain and regional brain atrophy in amyotrophic lateral sclerosis","volume":"28","author":"Mezzapesa D","year":"2007","journal-title":"AJNR Am J Neuroradiol"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.2217\/bmm.12.26"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.acra.2012.04.012"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.3109\/21678421.2013.812661"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0105632"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1789.2010.01171.x"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1556\/LP.1.2009.2.4"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1006\/brcg.1999.1145"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2008.03.057"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11910-015-0569-6"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2008.02.050"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2008.01.031"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mri.2007.03.025"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2008.08.045"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2008.09.053"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2006.08.018"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.3109\/21678421.2015.1074707"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2013-306839"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1080\/01688639608408283"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000002242"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181b6bbbd"}],"container-title":["European Journal of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fene.13163","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fene.13163","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ene.13163","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T07:48:21Z","timestamp":1695541701000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ene.13163"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10,18]]},"references-count":48,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,1]]}},"alternative-id":["10.1111\/ene.13163"],"URL":"https:\/\/doi.org\/10.1111\/ene.13163","archive":["Portico"],"relation":{},"ISSN":["1351-5101","1468-1331"],"issn-type":[{"value":"1351-5101","type":"print"},{"value":"1468-1331","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,10,18]]},"assertion":[{"value":"2016-05-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-08-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-10-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}