{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T23:22:26Z","timestamp":1791933746256,"version":"4.3.4"},"reference-count":41,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,10,2]],"date-time":"2016-10-02T00:00:00Z","timestamp":1475366400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009471","name":"EkstraStiftelsen Helse og Rehabilitering","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009471","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002712","name":"H\u00f8gskolen i Oslo og Akershus","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002712","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>To investigate the efficacy of chiropractic spinal manipulative therapy (<jats:styled-content style=\"fixed-case\">CSMT<\/jats:styled-content>) for migraineurs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a prospective three\u2010armed, single\u2010blinded, placebo, randomized controlled trial (<jats:styled-content style=\"fixed-case\">RCT<\/jats:styled-content>) of 17 months duration including 104 migraineurs with at least one migraine attack per month. The <jats:styled-content style=\"fixed-case\">RCT<\/jats:styled-content> was conducted at Akershus University Hospital, Oslo, Norway. Active treatment consisted of <jats:styled-content style=\"fixed-case\">CSMT<\/jats:styled-content>, whereas placebo was a sham push manoeuvre of the lateral edge of the scapula and\/or the gluteal region. The control group continued their usual pharmacological management. The <jats:styled-content style=\"fixed-case\">RCT<\/jats:styled-content> consisted of a 1\u2010month run\u2010in, 3 months intervention and outcome measures at the end of the intervention and at 3, 6 and 12 months follow\u2010up. The primary end\u2010point was the number of migraine days per month, whereas secondary end\u2010points were migraine duration, migraine intensity and headache index, and medicine consumption.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Migraine days were significantly reduced within all three groups from baseline to post\u2010treatment (<jats:italic>P<\/jats:italic> &lt; 0.001). The effect continued in the <jats:styled-content style=\"fixed-case\">CSMT<\/jats:styled-content> and placebo group at all follow\u2010up time points, whereas the control group returned to baseline. The reduction in migraine days was not significantly different between the groups (<jats:italic>P<\/jats:italic> &gt; 0.025 for interaction). Migraine duration and headache index were reduced significantly more in the <jats:styled-content style=\"fixed-case\">CSMT<\/jats:styled-content> than the control group towards the end of follow\u2010up (<jats:italic>P<\/jats:italic> = 0.02 and <jats:italic>P<\/jats:italic> = 0.04 for interaction, respectively). Adverse events were few, mild and transient. Blinding was strongly sustained throughout the <jats:styled-content style=\"fixed-case\">RCT<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>It is possible to conduct a manual\u2010therapy <jats:styled-content style=\"fixed-case\">RCT<\/jats:styled-content> with concealed placebo. The effect of <jats:styled-content style=\"fixed-case\">CSMT<\/jats:styled-content> observed in our study is probably due to a placebo response.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.13166","type":"journal-article","created":{"date-parts":[[2016,10,7]],"date-time":"2016-10-07T14:06:52Z","timestamp":1475849212000},"page":"143-153","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":54,"title":["Chiropractic spinal manipulative therapy for migraine: a three\u2010armed, single\u2010blinded, placebo, randomized controlled trial"],"prefix":"10.1111","volume":"24","author":[{"given":"A.","family":"Chaibi","sequence":"first","affiliation":[{"name":"Head and Neck Research Group Research Centre, Akershus University Hospital L\u00f8renskog Norway"},{"name":"Institute of Clinical Medicine Akershus University Hospital, University of Oslo Nordbyhagen Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. \u0160.","family":"Benth","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine Akershus University Hospital, University of Oslo Nordbyhagen Norway"},{"name":"H\u00d8KH Research Centre, Akershus University Hospital L\u00f8renskog Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. 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