{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T04:29:05Z","timestamp":1768883345103,"version":"3.49.0"},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,10,16]],"date-time":"2016-10-16T00:00:00Z","timestamp":1476576000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>Although early cerebellar symptoms are one of the exclusive criteria in the diagnosis of progressive supranuclear palsy (<jats:styled-content style=\"fixed-case\">PSP<\/jats:styled-content>), cerebellar involvement in <jats:styled-content style=\"fixed-case\">PSP<\/jats:styled-content> is evident both clinically and pathologically. However, structural analysis focusing on the cerebellum has not been previously studied in patients with <jats:styled-content style=\"fixed-case\">PSP<\/jats:styled-content>. We aimed to evaluate cerebellar involvement in <jats:styled-content style=\"fixed-case\">PSP<\/jats:styled-content> using a magnetic resonance imaging\u2010based segmental volumetric analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively enrolled 48 patients with <jats:styled-content style=\"fixed-case\">PSP<\/jats:styled-content> composed of 25 patients with <jats:styled-content style=\"fixed-case\">PSP<\/jats:styled-content>\u2013Richardson's syndrome (<jats:styled-content style=\"fixed-case\">RS<\/jats:styled-content>) and 23 patients with pure akinesia with gait freezing, 39 patients with Parkinson's disease (<jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>) and 34 healthy controls. Data on both the whole and segmented cerebellar volumes were analyzed using a fully automated procedure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A general linear model showed that whole cerebellar volume in patients with <jats:styled-content style=\"fixed-case\">PSP<\/jats:styled-content> was significantly smaller compared with that of patients with <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> or controls after controlling for age, sex and intracranial volume (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.34). In addition, patients with <jats:styled-content style=\"fixed-case\">PSP<\/jats:styled-content> exhibited decreased regional volume in the crus I, lobule <jats:styled-content style=\"fixed-case\">VIII<\/jats:styled-content>a and lobule <jats:styled-content style=\"fixed-case\">VIII<\/jats:styled-content>b, which play roles as secondary representations of motor tasks, compared with patients with <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> or controls. In subgroup analysis of <jats:styled-content style=\"fixed-case\">PSP<\/jats:styled-content>, volume loss in the whole and segmental cerebellum was more pronounced in patients with <jats:styled-content style=\"fixed-case\">PSP<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">RS<\/jats:styled-content> than in those with pure akinesia with gait freezing, <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> or control subjects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These data demonstrate that cerebellar atrophy is evident in patients with <jats:styled-content style=\"fixed-case\">PSP<\/jats:styled-content> and is especially prominent in the <jats:styled-content style=\"fixed-case\">PSP<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">RS<\/jats:styled-content> group. These findings increase understanding of the clinicopathological basis of cerebellar involvement in <jats:styled-content style=\"fixed-case\">PSP<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.13185","type":"journal-article","created":{"date-parts":[[2016,10,17]],"date-time":"2016-10-17T04:29:42Z","timestamp":1476678582000},"page":"212-218","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Volumetric analysis of the cerebellum in patients with progressive supranuclear palsy"],"prefix":"10.1111","volume":"24","author":[{"given":"Y.","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Neurology Yonsei University College of Medicine Seoul"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. 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