{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,12]],"date-time":"2025-04-12T09:47:48Z","timestamp":1744451268577},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,11,10]],"date-time":"2016-11-10T00:00:00Z","timestamp":1478736000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002924","name":"Federaci\u00f3n Espa\u00f1ola de Enfermedades Raras","doi-asserted-by":"publisher","award":["RD12\/0042\/0020"],"award-info":[{"award-number":["RD12\/0042\/0020"]}],"id":[{"id":"10.13039\/501100002924","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002924","name":"Federaci\u00f3n Espa\u00f1ola de Enfermedades Raras","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002924","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>The percentage of patients with clinical total anterior circulation infarct (<jats:styled-content style=\"fixed-case\">TACI<\/jats:styled-content>) syndrome treated with reperfusion therapies in the absence of intracranial large\u2010vessel occlusion (<jats:styled-content style=\"fixed-case\">ILVO<\/jats:styled-content>) was determined and their characteristics and outcome are described.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data from a population\u2010based, prospective, externally audited registry of all stroke patients treated with intravenous thrombolysis (<jats:styled-content style=\"fixed-case\">IVT<\/jats:styled-content>) and endovascular therapies in Catalonia from January 2011 to December 2013 were used. Patients with a baseline <jats:styled-content style=\"fixed-case\">TACI<\/jats:styled-content> and initial stroke severity measured by the National Institute of Health Stroke Scale (<jats:styled-content style=\"fixed-case\">NIHSS<\/jats:styled-content>) \u2265 8, evaluated less than 4.5 h post\u2010onset, for whom a vascular study prior to treatment was available (<jats:italic>n<\/jats:italic> = 1070) were selected. Clinical characteristics, outcome and radiological data for patients treated with <jats:styled-content style=\"fixed-case\">IVT<\/jats:styled-content> alone (<jats:italic>n<\/jats:italic> = 605) were compared between those with detected <jats:styled-content style=\"fixed-case\">ILVO<\/jats:styled-content> (<jats:italic>n<\/jats:italic> = 474) and non\u2010<jats:styled-content style=\"fixed-case\">ILVO<\/jats:styled-content> patients (<jats:italic>n<\/jats:italic> = 131).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 1070 patients met study criteria; non\u2010<jats:styled-content style=\"fixed-case\">ILVO<\/jats:styled-content> was found in 131 (12.2%). Analysing the 605 patients treated only with <jats:styled-content style=\"fixed-case\">IVT<\/jats:styled-content>, no significant differences were found between non\u2010<jats:styled-content style=\"fixed-case\">ILVO<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">ILVO<\/jats:styled-content> patients in age, sex, risk factors, time\u2010to\u2010treatment and type of radiological studies performed. Although non\u2010<jats:styled-content style=\"fixed-case\">ILVO<\/jats:styled-content> patients had lower initial stroke severity (<jats:italic>P<\/jats:italic> &lt; 0.001) and a better prognosis (<jats:italic>P<\/jats:italic> = 0.001), 51.3% had a poor outcome and 16% were deceased at 90 days. In 66.4% of patients without <jats:styled-content style=\"fixed-case\">ILVO<\/jats:styled-content>, a recent anterior territorial infarct was detected.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Intracranial artery patency was observed in 12.2% of <jats:styled-content style=\"fixed-case\">TACI<\/jats:styled-content> patients evaluated within 4.5 h. Although absence of <jats:styled-content style=\"fixed-case\">ILVO<\/jats:styled-content> was associated with slightly better prognosis, more than half had a poor outcome at 3 months.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.13187","type":"journal-article","created":{"date-parts":[[2016,11,10]],"date-time":"2016-11-10T07:40:12Z","timestamp":1478763612000},"page":"11-17","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Frequency and outcome of total anterior circulation strokes without intracranial large\u2010vessel occlusion"],"prefix":"10.1111","volume":"24","author":[{"given":"E.","family":"Giralt\u2010Steinhauer","sequence":"first","affiliation":[{"name":"Neurovascular Research Group Neurology Department Hospital del Mar Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Ois","sequence":"additional","affiliation":[{"name":"Neurovascular Research Group Neurology 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