{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T16:40:09Z","timestamp":1790700009951,"version":"4.1.0"},"reference-count":47,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,11,26]],"date-time":"2016-11-26T00:00:00Z","timestamp":1480118400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Catholic Medical Center Research Foundation"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2017,2]]},"abstract":"\n Background and purpose<\/jats:title>\n \n Reduction of metaiodobenzylguanidine (\n MIBG<\/jats:styled-content>\n ) uptake has been observed in almost all patients with Parkinson's disease (\n PD<\/jats:styled-content>\n ), associated with hyposmia, orthostatic hypotension and rapid eye movement sleep behavioral disorder (\n RBD<\/jats:styled-content>\n ). In contrast, a subgroup of patients with\n PD<\/jats:styled-content>\n with normal\n MIBG<\/jats:styled-content>\n uptake have been reported to have milder disease and preserved cognition compared with those with lower\n MIBG<\/jats:styled-content>\n . The aim of this study was to investigate whether non\u2010motor manifestations of\n PD<\/jats:styled-content>\n differ between patients with normal and abnormal myocardial MIBG uptake.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Among 160\n de\u2010novo<\/jats:italic>\n cases of\n PD<\/jats:styled-content>\n , 44 had normal\n MIBG<\/jats:styled-content>\n uptake. Twelve candidate non\u2010motor features were evaluated using questionnaires and laboratory tests.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Patients with decreased\n MIBG<\/jats:styled-content>\n uptake had more constipation,\n RBD<\/jats:styled-content>\n , cognitive impairment, hyposmia and orthostatic hypotension than did those with normal\n MIBG<\/jats:styled-content>\n uptake. On linear regression analysis, orthostatic hypotension, olfactory function and probable\n RBD<\/jats:styled-content>\n were significantly associated with\n MIBG<\/jats:styled-content>\n uptake in\n PD<\/jats:styled-content>\n . The principal component analysis showed that the group with normal\n MIBG<\/jats:styled-content>\n was not associated with non\u2010motor impairments.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n These results suggest that patients with\n PD<\/jats:styled-content>\n with normal\n MIBG<\/jats:styled-content>\n scans have a relatively low disease burden compared with those with abnormal\n MIBG<\/jats:styled-content>\n . Fewer synuclein pathologies in the myocardia and sympathetic ganglia in\n PD<\/jats:styled-content>\n with preserved\n MIBG<\/jats:styled-content>\n uptake might be associated with lower threshold patterns of Braak synuclein pathology for non\u2010motor manifestations compared with PD with decreased\n MIBG<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/ene.13206","type":"journal-article","created":{"date-parts":[[2016,11,26]],"date-time":"2016-11-26T00:54:05Z","timestamp":1480121645000},"page":"349-356","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":69,"title":["Normal \u2018heart\u2019 in Parkinson's disease: is this a distinct clinical phenotype?"],"prefix":"10.1111","volume":"24","author":[{"given":"J.\u2010S.","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Neurology College of Medicine The Catholic University of Korea Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.\u2010E.","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Neurology College of Medicine The Catholic University of Korea Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.\u2010S.","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Neurology College of Medicine The Catholic University of Korea Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.\u2010S.","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Neurology College of Medicine The Catholic University of Korea Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.\u2010W.","family":"Ryu","sequence":"additional","affiliation":[{"name":"Department of Neurology College of Medicine The Catholic University of Korea Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.\u2010U.","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Neurology College of Medicine The Catholic University of Korea Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.\u2010A.","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine College of Medicine The Catholic University of Korea Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I. 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