{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T21:16:02Z","timestamp":1790025362376,"version":"4.0.1"},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,12,9]],"date-time":"2016-12-09T00:00:00Z","timestamp":1481241600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>Despite extensive studies on post\u2010stroke depression (<jats:styled-content style=\"fixed-case\">PSD<\/jats:styled-content>), the role of the total burden of cerebral small\u2010vessel disease (<jats:styled-content style=\"fixed-case\">cSVD<\/jats:styled-content>) in its pathogenesis remains unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a magnetic resonance imaging (<jats:styled-content style=\"fixed-case\">MRI)<\/jats:styled-content>\u2010based cohort study to investigate the relationship between total <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> burden of <jats:styled-content style=\"fixed-case\">cSVD<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">PSD<\/jats:styled-content> among patients with first\u2010ever lacunar stroke. From June 2013 to January 2016, 374 patients were consecutively recruited. <jats:styled-content style=\"fixed-case\">PSD<\/jats:styled-content> was identified using the Chinese version of the Structured Clinical Interview for <jats:styled-content style=\"fixed-case\">DSM<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content>. Brain <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> presence of silent lacunar infarcts, white\u2010matter lesions, cerebral microbleeds and enlarged perivascular spaces was summed to an ordinal score between 0 and 4. Multivariable logistic regression analysis was performed to determine the contribution of total <jats:styled-content style=\"fixed-case\">MRI cSVD<\/jats:styled-content> burden in the prediction of PSD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ninety patients (24.1%) were diagnosed with <jats:styled-content style=\"fixed-case\">PSD<\/jats:styled-content> at 3\u00a0months after stroke. Only two <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> markers of <jats:styled-content style=\"fixed-case\">cSVD<\/jats:styled-content>, asymptomatic lacunar infarcts and white\u2010matter lesions, were related to <jats:styled-content style=\"fixed-case\">PSD<\/jats:styled-content> [odds ratio (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>), 3.167; 95% confidence interval (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>), 1.879\u20135.338; <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.001 and <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>, 2.284; 95% <jats:styled-content style=\"fixed-case\">CI,<\/jats:styled-content> 1.403\u20133.713; <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.001, respectively]. Moreover, higher total <jats:styled-content style=\"fixed-case\">MRI cSVD<\/jats:styled-content> burden was an independent predictor for <jats:styled-content style=\"fixed-case\">PSD<\/jats:styled-content> (high tertile <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>, 4.577; 95%<jats:styled-content style=\"fixed-case\"> CI,<\/jats:styled-content> 2.400\u20138.728; <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.001) after adjusting for individual <jats:styled-content style=\"fixed-case\">cSVD MRI<\/jats:styled-content> marker and other potential confounders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study demonstrated that greater total <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> burden of <jats:styled-content style=\"fixed-case\">cSVD<\/jats:styled-content> may predict the presence of <jats:styled-content style=\"fixed-case\">PSD<\/jats:styled-content> in patients with acute lacunar stroke.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.13213","type":"journal-article","created":{"date-parts":[[2016,12,9]],"date-time":"2016-12-09T05:16:57Z","timestamp":1481260617000},"page":"374-380","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":62,"title":["Total magnetic resonance imaging burden of cerebral small\u2010vessel disease is associated with post\u2010stroke depression in patients with acute lacunar stroke"],"prefix":"10.1111","volume":"24","author":[{"given":"X.","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Neurology Second Affiliated Hospital of Nanjing University of Chinese Medicine Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Neurology Second Affiliated Hospital of Nanjing University of Chinese Medicine Nanjing Jiangsu 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