{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T09:47:30Z","timestamp":1747820850598},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,1,23]],"date-time":"2017-01-23T00:00:00Z","timestamp":1485129600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>The aim of this study was to investigate the correlation between the duration of the <jats:styled-content style=\"fixed-case\">QT<\/jats:styled-content>c interval and the brain lesion load at the level of the structures involved in superior autonomic control (insula, cingulate cortex and amygdala\u2010hippocampus) in multiple sclerosis (<jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content>) patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty\u2010one consecutive patients with relapsing\u2212remitting <jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content> were recruited. The <jats:styled-content style=\"fixed-case\">QT<\/jats:styled-content> interval was measured manually in all 12 leads by a single blinded observer, with the longest <jats:styled-content style=\"fixed-case\">QT<\/jats:styled-content> value adjusted for heart rate by using the Bazett's formula. All patients performed a brain magnetic resonance imaging (<jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>) scan including three\u2010dimensional double inversion recovery and three volumetric fast\u2010field echo sequences. The following <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> measures were obtained: (i) global and regional cortical thickness (<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content>h); (ii) white matter lesion load volume; (iii) cortical damage blindly assessed by a trained observer who assigned, on the basis of the number of cortical lesions, a score from 0 to 5 for each of the brain areas analysed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In all, 16% of the patients had an increased <jats:styled-content style=\"fixed-case\">QT<\/jats:styled-content>c interval. The <jats:styled-content style=\"fixed-case\">QT<\/jats:styled-content>c interval was correlated with disease duration, cortical insular lesion volume and grey matter lesion volume in the three examined areas and inversely correlated with global and insular <jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content>h.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>An increased <jats:styled-content style=\"fixed-case\">QT<\/jats:styled-content>c interval in patients with <jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content> may have a cerebral origin possibly driven by involvement of the insular cortex. With the recent introduction in clinical practice of treatments with potential cardiac effects such as fingolimod, the recognition of a long <jats:styled-content style=\"fixed-case\">QT<\/jats:styled-content>c interval could be clinically crucial and should encourage appropriate electrocardiographic monitoring in order to prevent the risk of malignant ventricular pro\u2010arrhythmia and iatrogenic sudden death.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.13229","type":"journal-article","created":{"date-parts":[[2017,1,23]],"date-time":"2017-01-23T05:33:17Z","timestamp":1485149597000},"page":"491-496","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["<scp>QT<\/scp>c interval in patients with multiple sclerosis: an inference from the insula of Reil?"],"prefix":"10.1111","volume":"24","author":[{"given":"G.","family":"Turri","sequence":"first","affiliation":[{"name":"Department of Neurosciences, Biomedicine and Movement Sciences University Hospital of Verona Verona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Calabrese","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Biomedicine and Movement Sciences University Hospital of Verona Verona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Pancheri","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Biomedicine and Movement Sciences University Hospital of Verona Verona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Monaco","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Biomedicine and Movement Sciences University Hospital of Verona Verona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Gajofatto","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Biomedicine and Movement Sciences University Hospital of Verona Verona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Marafioti","sequence":"additional","affiliation":[{"name":"Cardiovascular and Thoracic Department University Hospital of Verona Verona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,1,23]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(87)91176-3"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2013.10.056"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.42.9.1727"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10286-006-0276-0"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000218177"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1159\/000089594"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2004.037531"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2014.07.226"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2015.04.026"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.12111429"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4598(199807)21:7<940::AID-MUS13>3.0.CO;2-U"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-4598(200008)23:8<1284::AID-MUS21>3.0.CO;2-R"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms160816920"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(91)90301-M"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2015.02.002"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0404.2000.101002085.x"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(93)90029-X"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2004.01.012"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22366"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/heart.89.11.1363"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.200033797"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31820a0cc4"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181f5d4da"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e318220abd4"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-006-0503-6"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1177\/1352458511408476"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.paf.0000176277.15834.d3"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1177\/1352458512438456"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1177\/1352458511410344"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.114.002085"}],"container-title":["European Journal of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fene.13229","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ene.13229","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T11:24:47Z","timestamp":1695554687000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ene.13229"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1,23]]},"references-count":30,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,3]]}},"alternative-id":["10.1111\/ene.13229"],"URL":"https:\/\/doi.org\/10.1111\/ene.13229","archive":["Portico"],"relation":{},"ISSN":["1351-5101","1468-1331"],"issn-type":[{"value":"1351-5101","type":"print"},{"value":"1468-1331","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1,23]]},"assertion":[{"value":"2016-09-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-11-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-01-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}