{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T18:01:21Z","timestamp":1790791281420,"version":"4.1.0"},"reference-count":19,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,2,10]],"date-time":"2017-02-10T00:00:00Z","timestamp":1486684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Medtronic International S\u00e0rl"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:sec><jats:label\/><jats:p>The aim of this review was to provide strong clinical evidence of the efficacy of deep brain stimulation (DBS) of the globus pallidus internus (GPi) in isolated inherited or idiopathic dystonia. Eligible studies were identified after a systematic literature review of the effects of bilateral <jats:styled-content style=\"fixed-case\">GP<\/jats:styled-content>i\u2010<jats:styled-content style=\"fixed-case\">DBS<\/jats:styled-content> in isolated dystonia. Absolute and percentage changes from baseline in the Burke\u2013Fahn\u2013Marsden Dystonia Rating Scale (<jats:styled-content style=\"fixed-case\">BFMDRS<\/jats:styled-content>) motor and disability scores were pooled, and associations between treatment effect and patient characteristics were explored using meta\u2010regression. In total, 24 studies were included in the meta\u2010analysis, comprising 523 patients. The mean absolute and percentage improvements in <jats:styled-content style=\"fixed-case\">BFMDRS<\/jats:styled-content> motor score at the last follow\u2010up (mean 32.5 months; 24 studies) were 26.6 points [95% confidence interval <jats:styled-content style=\"fixed-case\">(CI),<\/jats:styled-content> 22.4\u201330.8] and 65.2% (95% CI, 59.6\u201370.7), respectively. The corresponding changes in disability score at the last follow\u2010up (mean 32.9 months; 14 studies) were 6.4 points (95% CI, 5.0\u20137.8) and 58.6% (95% CI, 50.3\u201366.9). Multivariate meta\u2010regression of absolute scores indicated that higher <jats:styled-content style=\"fixed-case\">BFMDRS<\/jats:styled-content> motor and disability scores before surgery, together with younger age at time of surgery, were the main factors associated with significantly better <jats:styled-content style=\"fixed-case\">DBS<\/jats:styled-content> outcomes at the latest follow\u2010up. Reporting of safety data was frequently inconsistent and could not be included in the meta\u2010analysis. In conclusion, patients with isolated inherited or idiopathic dystonia significantly improved after <jats:styled-content style=\"fixed-case\">GP<\/jats:styled-content>i\u2010<jats:styled-content style=\"fixed-case\">DBS<\/jats:styled-content>. Better outcomes were associated with greater dystonia severity at baseline. These findings should be taken into consideration for improving patient selection for <jats:styled-content style=\"fixed-case\">DBS<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.13255","type":"journal-article","created":{"date-parts":[[2017,2,10]],"date-time":"2017-02-10T11:52:40Z","timestamp":1486727560000},"page":"552-560","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":174,"title":["Efficacy of pallidal stimulation in isolated dystonia: a systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"24","author":[{"given":"E.","family":"Moro","sequence":"first","affiliation":[{"name":"Division of Neurology CHU de Grenoble Universit\u00e9 Grenoble Alpes INSERM U1416 Grenoble France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"LeReun","sequence":"additional","affiliation":[{"name":"Independent biostatistician Sainte\u2010Anne Guadeloupe"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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