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Risk factors related to this observation have not been defined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Information regarding personal history of skin tumors, pigmentation phenotype, and skin reaction to sun exposure were collected from 266 <jats:styled-content style=\"fixed-case\">DM<\/jats:styled-content> patients who were enrolled in the <jats:styled-content style=\"fixed-case\">US<\/jats:styled-content> National Institutes of Health National Registry of Myotonic Dystrophy and Facioscapulohumeral Muscular Dystrophy Patients and Family Members.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seventy\u2010seven subjects reported having skin tumors that were either benign (<jats:italic>n<\/jats:italic> = 31), malignant (<jats:italic>n<\/jats:italic> = 32) or both (<jats:italic>n<\/jats:italic> = 14). Female gender [odds ratio (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>) = 2.27, 95% confidence interval (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>) 1.02\u20135.05, <jats:italic>P<\/jats:italic> = 0.04], older age (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> = 1.10, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.05\u20131.16, <jats:italic>P<\/jats:italic> &lt; 0.001) and <jats:styled-content style=\"fixed-case\">DM<\/jats:styled-content>1 subtype (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> = 3.42, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.27\u20139.26, <jats:italic>P<\/jats:italic> = 0.02) were associated with a malignant skin tumor. The associations between malignant skin tumors and known risk factors [light eye color (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> = 1.62, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.78\u20133.39, <jats:italic>P<\/jats:italic> = 0.20), light skin complexion (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> = 1.31, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.63\u20132.73, <jats:italic>P<\/jats:italic> = 0.48) and moderate\/extensive face freckles (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> = 1.47, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.50\u20134.34, <jats:italic>P<\/jats:italic> = 0.49)] were modest. Strong, but not statistically significant, associations were noted with sunburn reactions when exposed to sunlight (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> = 4.28, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.91\u201319.95, <jats:italic>P<\/jats:italic> = 0.06, and <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> = 2.19, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.67\u20137.09, <jats:italic>P<\/jats:italic> = 0.19, for sunburn with and without blistering, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Although our study was limited by small sample size, the risk factors for malignant skin tumors in <jats:styled-content style=\"fixed-case\">DM<\/jats:styled-content> strongly resemble the general population. It is recommended that <jats:styled-content style=\"fixed-case\">DM<\/jats:styled-content> patients adhere to sun exposure protective behavior.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.13276","type":"journal-article","created":{"date-parts":[[2017,3,20]],"date-time":"2017-03-20T06:32:38Z","timestamp":1489991558000},"page":"713-718","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Pigmentation phenotype, photosensitivity and skin neoplasms in patients with myotonic dystrophy"],"prefix":"10.1111","volume":"24","author":[{"given":"S. M.","family":"Gadalla","sequence":"first","affiliation":[{"name":"Clinical Genetics Branch Division of Cancer Epidemiology and Genetics National Cancer Institute NIH Bethesda MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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