{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T12:43:08Z","timestamp":1774528988087,"version":"3.50.1"},"reference-count":16,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,3,15]],"date-time":"2017-03-15T00:00:00Z","timestamp":1489536000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"AIRAlzh Onlus-COOP Italia"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>Performance on gambling tasks in Parkinson's disease (<jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>) is of particular interest, as pathological gambling is often associated with dopamine replacement therapy in these patients. We aimed to evaluate the effects of transcranial direct current stimulation (<jats:styled-content style=\"fixed-case\">tDCS<\/jats:styled-content>) over the right dorsolateral prefrontal cortex (<jats:styled-content style=\"fixed-case\">DLPFC<\/jats:styled-content>) in modulating gambling behaviour in <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We assessed the effects of cathodal <jats:styled-content style=\"fixed-case\">tDCS<\/jats:styled-content> over the right <jats:styled-content style=\"fixed-case\">DLPFC<\/jats:styled-content> during the Iowa Gambling Task in 20 patients with <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>, compared with sham stimulation. We then conducted a second experimental design, assessing the effects of anodal <jats:styled-content style=\"fixed-case\">tDCS<\/jats:styled-content> over the right DLPFC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We observed that cathodal <jats:styled-content style=\"fixed-case\">tDCS<\/jats:styled-content> over the right <jats:styled-content style=\"fixed-case\">DLPFC<\/jats:styled-content> increased Iowa Gambling Task scores compared with sham stimulation. In the second experimental design, we did not find significant differences between anodal and sham <jats:styled-content style=\"fixed-case\">tDCS<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Cathodal <jats:styled-content style=\"fixed-case\">tDCS<\/jats:styled-content> over the right <jats:styled-content style=\"fixed-case\">DLPFC<\/jats:styled-content> possibly reduces the pathological overdrive in frontostriatal networks in patients with <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> on dopaminergic medication, thus modulating impulsive and risky decision\u2010making.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.13286","type":"journal-article","created":{"date-parts":[[2017,3,15]],"date-time":"2017-03-15T08:48:44Z","timestamp":1489567724000},"page":"751-754","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Modulating risky 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