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Amnestic <jats:styled-content style=\"fixed-case\">VCI<\/jats:styled-content> was defined as memory impairment; non\u2010amnestic <jats:styled-content style=\"fixed-case\">VCI<\/jats:styled-content> was any other subdomain impairment. Associations of <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> metrics [log\u2010transformed total ischemic lesion load (log <jats:styled-content style=\"fixed-case\">TILL<\/jats:styled-content>), mesiotemporal atrophy (<jats:styled-content style=\"fixed-case\">MTA<\/jats:styled-content>) score, hippocampal mean diffusivity (hip<jats:styled-content style=\"fixed-case\">MD<\/jats:styled-content>)] with cognitive performance were assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A hundred and eight patients, 47 with amnestic VCI and 21 with non\u2010amnestic <jats:styled-content style=\"fixed-case\">VCI<\/jats:styled-content>, were assessed. A higher <jats:styled-content style=\"fixed-case\">MTA<\/jats:styled-content> (odds ratio 12.89, <jats:italic>P<\/jats:italic> = 0.001) and left hip<jats:styled-content style=\"fixed-case\">MD<\/jats:styled-content> (odds ratio 4.43, <jats:italic>P<\/jats:italic> = 0.003) contributed to amnestic <jats:styled-content style=\"fixed-case\">VCI<\/jats:styled-content> versus normal. Age\u2010adjusted <jats:italic>fluency<\/jats:italic> correlated with log <jats:styled-content style=\"fixed-case\">TILL<\/jats:styled-content> (<jats:italic>P<\/jats:italic> = 0.002). Age\u2010adjusted <jats:italic>memory<\/jats:italic> was associated with left hip<jats:styled-content style=\"fixed-case\">MD<\/jats:styled-content> (<jats:italic>P<\/jats:italic> = 0.001), <jats:styled-content style=\"fixed-case\">MTA<\/jats:styled-content> (<jats:italic>P<\/jats:italic> &lt; 0.001) but not log <jats:styled-content style=\"fixed-case\">TILL<\/jats:styled-content> (<jats:italic>P<\/jats:italic> = 0.14). Left hip<jats:styled-content style=\"fixed-case\">MD<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> MTA<\/jats:styled-content> and smoking showed classification potential between amnestic <jats:styled-content style=\"fixed-case\">VCI<\/jats:styled-content> versus normal (area 0.859, <jats:italic>P<\/jats:italic> &lt; 0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Neuroimaging assists stratification in amnestic <jats:styled-content style=\"fixed-case\">VCI<\/jats:styled-content> characterized by hippocampal changes and in non\u2010amnestic <jats:styled-content style=\"fixed-case\">VCI<\/jats:styled-content> by higher ischemic burden. <jats:styled-content style=\"fixed-case\">MTA<\/jats:styled-content> and hippocampal diffusivity show diagnostic biomarker potential.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.13299","type":"journal-article","created":{"date-parts":[[2017,5,26]],"date-time":"2017-05-26T08:42:45Z","timestamp":1495788165000},"page":"902-911","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Mesiotemporal atrophy and hippocampal diffusivity distinguish amnestic from non\u2010amnestic vascular cognitive impairment"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0133-9842","authenticated-orcid":false,"given":"A. 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