{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T15:03:01Z","timestamp":1782831781865,"version":"3.54.5"},"reference-count":27,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2017,5,15]],"date-time":"2017-05-15T00:00:00Z","timestamp":1494806400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008373","name":"Takeda Pharmaceutical Company","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008373","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>Previous studies have reported that diabetes is a risk factor for both all\u2010cause and vascular dementia; however, diabetes as a risk factor for Alzheimer's disease (<jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>) remains controversial. Therefore, the aim was to elucidate the association between diabetes and early\u2010onset <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A case\u2013control study was conducted using a population\u2010based database that included medical and pharmacy claims and insurance eligibility data, from beneficiaries of corporate employees and their dependent family members. Cases were aged 40\u201364 years and were first prescribed medications for <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> between 2005 and 2016. Up to four controls matched for age, sex and hospital type were included for each case. Data were analyzed using conditional logistic regression and compared between the sexes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Data from 371 patients with <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> (mean age 56.3 \u00b1 5.3 years; 48% female) and 1484 controls were analyzed. Use of antidepressants, antipsychotics and antithrombotics during the index month was higher amongst patients with <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> (19.4%, 34.5% and 11.3%, respectively) than amongst controls (2.9%, 10.3% and 7.3%, respectively). Our findings suggest no evidence for an association between diabetes and risk of early\u2010onset <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> (adjusted odds ratio 1.31; 95% confidence interval 0.90\u20131.92). In the subgroup analyses, adjusted odds ratios in patients with diabetes were 0.73 (95% confidence interval 0.38\u20131.39) and 1.68 (95% confidence interval 1.06\u20132.67) for female and male patients, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>There is no apparent association between diabetes and risk of early\u2010onset <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> in the total study population, although a weak association was observed amongst male patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.13312","type":"journal-article","created":{"date-parts":[[2017,5,15]],"date-time":"2017-05-15T08:56:37Z","timestamp":1494838597000},"page":"944-949","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Diabetes mellitus and risk of early\u2010onset Alzheimer's disease: a population\u2010based case\u2013control 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