{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T19:52:02Z","timestamp":1784749922664,"version":"3.55.0"},"reference-count":20,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,5,6]],"date-time":"2017-05-06T00:00:00Z","timestamp":1494028800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2017,6]]},"abstract":"Background and purpose<\/jats:title>New criteria for the diagnosis of multiple sclerosis (MS<\/jats:styled-content>) and discovery of myelin oligodendrocyte glycoprotein (MOG<\/jats:styled-content>) or aquaporin\u20104 (AQP<\/jats:styled-content>4) antibodies (Abs) have changed the management of optic neuritis (ON<\/jats:styled-content>). Our aim was to specify, in view of these recent advances, the etiologies of acute demyelinating ON<\/jats:styled-content> for consecutive patients.<\/jats:p><\/jats:sec>Methods<\/jats:title>Retrospective database analysis was undertaken of consecutive adult patients with acute ON<\/jats:styled-content> admitted from 1 December 2014 to 31 January 2016. Diagnosis of MS<\/jats:styled-content> was made according to the 2010 McDonald criteria. Patients with Abs to AQP<\/jats:styled-content>4 or MOG<\/jats:styled-content> were classified as ON<\/jats:styled-content>\u2010AQP<\/jats:styled-content>4 and ON<\/jats:styled-content>\u2010MOG<\/jats:styled-content>, respectively. Patients who did not fulfill the diagnostic criteria and were negative for AQP<\/jats:styled-content>4 and MOG<\/jats:styled-content> Ab tests were classified as having idiopathic ON<\/jats:styled-content>.<\/jats:p><\/jats:sec>Results<\/jats:title>Of 110 patients assessed, 78 had ON<\/jats:styled-content> related to MS<\/jats:styled-content> (70.9%). All patients without MS<\/jats:styled-content> were tested for AQP<\/jats:styled-content>4 and MOG<\/jats:styled-content> Abs: 11 had MOG<\/jats:styled-content> Ab (10%), 5 had AQP<\/jats:styled-content>4 Ab (4.5%) and 16 were considered as having idiopathic ON<\/jats:styled-content> (14.5%). Presence of intrathecal IgG oligoclonal bands was strongly associated with MS<\/jats:styled-content> (mean, 88.4% vs. 34.4% in patients without MS<\/jats:styled-content>; after Bonferroni correction, P<\/jats:italic> < 0.0001).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Optic neuritis related to MOG<\/jats:styled-content> Ab was the second cause identified of demyelinating ON<\/jats:styled-content> in our center. Idiopathic ON<\/jats:styled-content> was as frequent as both ON<\/jats:styled-content>\u2010AQP<\/jats:styled-content>4 and ON<\/jats:styled-content>\u2010MOG<\/jats:styled-content> combined.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.13315","type":"journal-article","created":{"date-parts":[[2017,5,6]],"date-time":"2017-05-06T07:32:44Z","timestamp":1494055964000},"page":"875-879","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Etiologies of acute demyelinating optic neuritis: an observational study of 110 patients"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6291-8771","authenticated-orcid":false,"given":"R.","family":"Deschamps","sequence":"first","affiliation":[{"name":"Department of Neurology Fondation Ophtalmologique Adolphe de Rothschild 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