{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T20:15:41Z","timestamp":1787170541570,"version":"build-2736575974"},"reference-count":34,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2017,5,18]],"date-time":"2017-05-18T00:00:00Z","timestamp":1495065600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2013R1A1A2058612"],"award-info":[{"award-number":["2013R1A1A2058612"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003621","name":"Ministry of Science, ICT and Future Planning","doi-asserted-by":"publisher","award":["NRF\u20102014M3C7A1046050"],"award-info":[{"award-number":["NRF\u20102014M3C7A1046050"]}],"id":[{"id":"10.13039\/501100003621","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2017,7]]},"abstract":"\n Background and purpose<\/jats:title>\n \n The occult changes in normal\u2010appearing white matter (\n NAWM<\/jats:styled-content>\n ) were investigated and compared amongst patients with neuromyelitis optica spectrum disorder (\n NMOSD<\/jats:styled-content>\n ), patients with multiple sclerosis (\n MS<\/jats:styled-content>\n ) and healthy controls (\n HC<\/jats:styled-content>\n s) by applying tract\u2010based spatial statistics to diffusion tensor imaging (\n DTI<\/jats:styled-content>\n ) data.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Diffusion tensor imaging was performed with a 3\u2010T scanner in 93 patients with\n NMOSD<\/jats:styled-content>\n , 53 patients with\n MS<\/jats:styled-content>\n and 43\n HC<\/jats:styled-content>\n s. Voxel\u2010wise statistical analyses of the\n DTI<\/jats:styled-content>\n data were performed using tract\u2010based spatial statistics.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Compared to\n HC<\/jats:styled-content>\n s, patients with\n NMOSD<\/jats:styled-content>\n had significantly lower mean global fractional anisotropy, higher mean diffusivity and radial diffusivity, and no significant differences in axial diffusivity in their\n NAWM<\/jats:styled-content>\n . Patients with\n MS<\/jats:styled-content>\n demonstrated significantly lower mean global fractional anisotropy and higher mean diffusivity, axial diffusivity and radial diffusivity in the\n NAWM<\/jats:styled-content>\n than did patients with\n NMOSD<\/jats:styled-content>\n and\n HC<\/jats:styled-content>\n s. Compared to patients with\n NMOSD<\/jats:styled-content>\n , patients with\n MS<\/jats:styled-content>\n had\n NAWM<\/jats:styled-content>\n damage that was more extensive, particularly in the inferior cerebellar peduncle, external capsule, cingulum, superior fronto\u2010occipital fasciculus and uncinate fasciculus.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Using\n DTI<\/jats:styled-content>\n , widespread occult damage was demonstrated in the\n NAWM<\/jats:styled-content>\n of patients with\n NMOSD<\/jats:styled-content>\n . However, the\n NAWM<\/jats:styled-content>\n was less affected in patients with\n NMOSD<\/jats:styled-content>\n than it was in patients with\n MS<\/jats:styled-content>\n ; specifically, the axonal injuries and diffusion abnormalities in the association fibers were more severe in patients with\n MS<\/jats:styled-content>\n than they were in patients with\n NMOSD<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/ene.13321","type":"journal-article","created":{"date-parts":[[2017,5,18]],"date-time":"2017-05-18T07:45:29Z","timestamp":1495093529000},"page":"966-973","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Diffusion tensor imaging of normal\u2010appearing white matter in patients with neuromyelitis optica spectrum disorder and multiple sclerosis"],"prefix":"10.1111","volume":"24","author":[{"given":"S.\u2010H.","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Neurology Institute and Hospital of National Cancer Center Goyang\u2010si Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Kwak","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Hanyang University Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.\u2010W.","family":"Hyun","sequence":"additional","affiliation":[{"name":"Department of Neurology Institute and Hospital of National Cancer Center Goyang\u2010si Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Joung","sequence":"additional","affiliation":[{"name":"Department of Neurology Institute and Hospital of National Cancer Center Goyang\u2010si Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. H.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Radiology Institute and Hospital of National Cancer Center Goyang\u2010si Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.\u2010H.","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Hanyang University Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.\u2010M.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Hanyang University Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8672-8419","authenticated-orcid":false,"given":"H. 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