{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T20:41:25Z","timestamp":1789677685709,"version":"4.0.1"},"reference-count":24,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2017,6,25]],"date-time":"2017-06-25T00:00:00Z","timestamp":1498348800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>Randomized controlled trials have shown that bridging endovascular therapy (EVT) after intravenous thrombolysis (<jats:styled-content style=\"fixed-case\">IVT<\/jats:styled-content>) therapy improves outcome in patients with stroke with large\u2010artery anterior circulation stroke compared with <jats:styled-content style=\"fixed-case\">IVT<\/jats:styled-content> alone. It remains unknown whether <jats:styled-content style=\"fixed-case\">IVT<\/jats:styled-content> adds any benefit to EVT in these patients. The aim of this study was to assess recanalization rates and thrombus dislocation before initiation of <jats:styled-content style=\"fixed-case\">EVT<\/jats:styled-content> in patients receiving bridging therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All patients in the Bernese stroke registry (2008\u20132015) in whom bridging therapy was considered were included in this analysis. Relevant recanalization before <jats:styled-content style=\"fixed-case\">EVT<\/jats:styled-content>, thrombus dislocation and increase in thrombus load between initial and control imaging were assessed retrospectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 319 patients were included. Relevant recanalization before <jats:styled-content style=\"fixed-case\">EVT<\/jats:styled-content> occurred in 8.8% and thrombus dislocation in 7.2% of patients before <jats:styled-content style=\"fixed-case\">EVT<\/jats:styled-content>. Recanalization rates were significantly higher in distal compared with large and more proximal vessel occlusions of the anterior circulation (occlusion of internal carotid artery, 5.4%; middle cerebral artery segment M1, 8.1%; middle cerebral artery segment M2, 17.6%) and in drip\u2010and\u2010ship patients compared with mother\u2010ship patients. In multivariable regression analysis the occlusion site was the only independent predictor of relevant recanalization before <jats:styled-content style=\"fixed-case\">EVT<\/jats:styled-content> (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.046).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Relevant recanalization after <jats:styled-content style=\"fixed-case\">IVT<\/jats:styled-content> and prior to <jats:styled-content style=\"fixed-case\">EVT<\/jats:styled-content> in patients receiving bridging therapy was highly dependent on the occlusion site. These findings suggest that future randomized controlled trials should consider occlusion site and treatment paradigm to specify patients who benefit most from bridging therapy in comparison to <jats:styled-content style=\"fixed-case\">EVT<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">IVT<\/jats:styled-content> alone.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.13330","type":"journal-article","created":{"date-parts":[[2017,6,26]],"date-time":"2017-06-26T04:34:35Z","timestamp":1498451675000},"page":"1016-1021","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":68,"title":["Impact of intravenous thrombolysis on recanalization rates in patients with stroke treated with bridging therapy"],"prefix":"10.1111","volume":"24","author":[{"given":"L.","family":"Mueller","sequence":"first","affiliation":[{"name":"Department of Neurology Inselspital University Hospital Bern, Bern and University of Bern Bern"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Pult","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Neuroradiology Inselspital University Hospital Bern and University of Bern Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Meisterernst","sequence":"additional","affiliation":[{"name":"Department of Neurology Inselspital University Hospital Bern, Bern and University of Bern Bern"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. R.","family":"Heldner","sequence":"additional","affiliation":[{"name":"Department of Neurology Inselspital University Hospital Bern, Bern and University of Bern Bern"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.\u2010L.","family":"Mono","sequence":"additional","affiliation":[{"name":"Department of Neurology Inselspital University Hospital Bern, Bern and University of Bern Bern"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Kurmann","sequence":"additional","affiliation":[{"name":"Department of Neurology Inselspital University Hospital Bern, Bern and University of Bern Bern"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Buehlmann","sequence":"additional","affiliation":[{"name":"Department of Neurology Inselspital University Hospital Bern, Bern and University of Bern Bern"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"U.","family":"Fischer","sequence":"additional","affiliation":[{"name":"Department of Neurology Inselspital University Hospital Bern, Bern and University of Bern Bern"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. P.","family":"Mattle","sequence":"additional","affiliation":[{"name":"Department of Neurology Inselspital University Hospital Bern, Bern and University of Bern Bern"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Arnold","sequence":"additional","affiliation":[{"name":"Department of Neurology Inselspital University Hospital Bern, Bern and University of Bern Bern"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Mordasini","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Neuroradiology Inselspital University Hospital Bern and University of Bern Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Gralla","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Neuroradiology Inselspital University Hospital Bern and University of Bern Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Schroth","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Neuroradiology Inselspital University Hospital Bern and University of Bern Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"El\u2010Koussy","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Neuroradiology Inselspital University Hospital Bern and University of Bern Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8288-6102","authenticated-orcid":false,"given":"S.","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Neurology Inselspital University Hospital Bern, Bern and University of Bern Bern"},{"name":"Department of Diagnostic and Interventional Neuroradiology Inselspital University Hospital Bern and University of Bern Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,6,25]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199512143332401"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0804656"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1414905"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1503780"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1415061"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1411587"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1414792"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(16)30177-6"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.116.013372"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.110.592535"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.110.609693"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1747-4949.2011.00750.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awt246"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.114.004796"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.115.010250"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-014-7401-0"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.116.014181"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000251788.03914.00"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000206443.96112.d9"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.31.8.1812"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2014.12.015"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2013.01.097"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2015.01.008"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2013.01.001"}],"container-title":["European Journal of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fene.13330","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ene.13330","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T08:09:01Z","timestamp":1695542941000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ene.13330"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6,25]]},"references-count":24,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2017,8]]}},"alternative-id":["10.1111\/ene.13330"],"URL":"https:\/\/doi.org\/10.1111\/ene.13330","archive":["Portico"],"relation":{},"ISSN":["1351-5101","1468-1331"],"issn-type":[{"value":"1351-5101","type":"print"},{"value":"1468-1331","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6,25]]},"assertion":[{"value":"2016-10-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-04-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-06-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}