{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T14:01:58Z","timestamp":1790431318044,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2017,6,16]],"date-time":"2017-06-16T00:00:00Z","timestamp":1497571200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"French Ministry of Health","award":["2009-A00533-54"],"award-info":[{"award-number":["2009-A00533-54"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>Motoric cognitive risk (<jats:styled-content style=\"fixed-case\">MCR<\/jats:styled-content>) syndrome is a pre\u2010dementia syndrome. There is little information on the cognitive profile of individuals with <jats:styled-content style=\"fixed-case\">MCR<\/jats:styled-content> syndrome and its overlap with mild cognitive impairment (<jats:styled-content style=\"fixed-case\">MCI<\/jats:styled-content>) syndrome. This study aimed to examine and compare the cognitive performance of non\u2010demented older community dwellers with and without <jats:styled-content style=\"fixed-case\">MCR<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">MCI<\/jats:styled-content> syndromes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 291 non\u2010demented individuals were selected from the Gait and Alzheimer Interactions Tracking study, which is a cross\u2010sectional study. All participants were referred to a memory clinic. Individuals with and without <jats:styled-content style=\"fixed-case\">MCR<\/jats:styled-content> were separated into those with and without <jats:styled-content style=\"fixed-case\">MCI<\/jats:styled-content>. Cognitive performance was measured using the scores of the Mini Mental Status Examination, Frontal Assessment Battery, Free and Cued Selective Reminding Test, Trail Making Test part A and B, and Stroop test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The prevalence of <jats:styled-content style=\"fixed-case\">MCI<\/jats:styled-content> was 40.1% and that of <jats:styled-content style=\"fixed-case\">MCR<\/jats:styled-content> was 18.2%, with a higher prevalence of <jats:styled-content style=\"fixed-case\">MCI<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">MCR<\/jats:styled-content> group compared with the non\u2010<jats:styled-content style=\"fixed-case\">MCR<\/jats:styled-content> group (47.2% vs. 39.5%). Individuals with <jats:styled-content style=\"fixed-case\">MCR<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">MCI<\/jats:styled-content> syndromes had poorer cognitive performance in all domains compared with those without <jats:styled-content style=\"fixed-case\">MCR<\/jats:styled-content> (<jats:italic>P<\/jats:italic> &lt; 0.005), except for the ratio part <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content>: part I of the Stroop test (<jats:italic>P<\/jats:italic> = 0.345). The association between cognitive performance and <jats:styled-content style=\"fixed-case\">MCR<\/jats:styled-content> syndrome was worse on the Mini Mental Status Examination score [effect size, \u22120.57 (95% confidence interval, \u22121.02 to \u22120.12)] and Trail Making Test part B [effect size, 0.59 (95% confidence interval, 0.14\u20131.04)] in individuals with <jats:styled-content style=\"fixed-case\">MCR<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">MCI<\/jats:styled-content> syndromes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Motoric cognitive risk syndrome is associated with low global cognitive performance. Association of <jats:styled-content style=\"fixed-case\">MCR<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">MCI<\/jats:styled-content> syndromes is characterized by a worse cognitive performance.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.13331","type":"journal-article","created":{"date-parts":[[2017,6,16]],"date-time":"2017-06-16T10:56:42Z","timestamp":1497610602000},"page":"1047-1054","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["The spectrum of pre\u2010dementia stages: cognitive profile of motoric cognitive risk syndrome and relationship with mild cognitive impairment"],"prefix":"10.1111","volume":"24","author":[{"given":"H.","family":"Sekhon","sequence":"first","affiliation":[{"name":"Division of Experimental Medicine Faculty of Medicine McGill University Montreal QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Allali","sequence":"additional","affiliation":[{"name":"Department of Neurology Geneva University Hospital and University of Geneva Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. P.","family":"Launay","sequence":"additional","affiliation":[{"name":"Division of Geriatric Medicine and Geriatric Rehabilitation Department of Medicine Lausanne University Hospital Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Chabot","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Geriatric Medicine Sir Mortimer B. Davis \u2010 Jewish General Hospital and Lady Davis Institute for Medical Research McGill University Montreal Quebec"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1921-9443","authenticated-orcid":false,"given":"O.","family":"Beauchet","sequence":"additional","affiliation":[{"name":"Division of Experimental Medicine Faculty of Medicine McGill University Montreal QC Canada"},{"name":"Department of Medicine Division of Geriatric Medicine Sir Mortimer B. 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