{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T12:23:59Z","timestamp":1761395039435,"version":"3.37.3"},"reference-count":20,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2017,6,21]],"date-time":"2017-06-21T00:00:00Z","timestamp":1498003200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Synergy- Munich Cluster for Systems Neurology."}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>Aseptic infections of the central nervous system (<jats:styled-content style=\"fixed-case\">CNS<\/jats:styled-content>) are frequently observed in Germany. However, no study has systematically addressed the spectrum of aseptic <jats:styled-content style=\"fixed-case\">CNS<\/jats:styled-content> infections in Germany.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data on 191 adult patients diagnosed from January 2007 to December 2014 with aseptic meningitis or encephalitis\/meningoencephalitis at our hospital were collected by chart review and analyzed for demographic, clinical and laboratory findings. Patients were stratified according to the causative virus and findings were compared between groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In our cohort, meningitis was caused in 36% by enterovirus (<jats:styled-content style=\"fixed-case\">EV<\/jats:styled-content>), 15% by herpes simplex virus (<jats:styled-content style=\"fixed-case\">HSV<\/jats:styled-content>), 12% by varicella zoster virus (<jats:styled-content style=\"fixed-case\">VZV<\/jats:styled-content>) and 5% by tick borne encephalitis (<jats:styled-content style=\"fixed-case\">TBE<\/jats:styled-content>). Encephalitis\/meningoencephalitis was caused in 13% by <jats:styled-content style=\"fixed-case\">HSV<\/jats:styled-content>, 13% by <jats:styled-content style=\"fixed-case\">VZV<\/jats:styled-content>, and three out of 11 tested patients were positive for <jats:styled-content style=\"fixed-case\">TBE<\/jats:styled-content>. The highest incidence of <jats:styled-content style=\"fixed-case\">EV<\/jats:styled-content> infections was between 25 and 35 years and of <jats:styled-content style=\"fixed-case\">HSV<\/jats:styled-content> infections between 30 and 60 years. <jats:styled-content style=\"fixed-case\">VZV<\/jats:styled-content> infections had a bimodal distribution peaking below 30 and above 70 years. <jats:styled-content style=\"fixed-case\">VZV<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">EV<\/jats:styled-content> infections were more frequently observed during summer, whereas <jats:styled-content style=\"fixed-case\">HSV<\/jats:styled-content> infections showed no seasonal preference. Inflammatory changes in cerebrospinal fluid (<jats:styled-content style=\"fixed-case\">CSF<\/jats:styled-content>) were highest in <jats:styled-content style=\"fixed-case\">HSV<\/jats:styled-content> and lowest in <jats:styled-content style=\"fixed-case\">EV<\/jats:styled-content> infections.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Polymerase chain reaction tests for <jats:styled-content style=\"fixed-case\">HSV<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> VZV<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">EV<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">CSF<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">TBE<\/jats:styled-content> serology determined the causative virus in over 60% of tested patients. The age of affected patients, seasonal distribution, disease course and inflammatory changes in <jats:styled-content style=\"fixed-case\">CSF<\/jats:styled-content> differ between groups of patients affected by the most common viral infections.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.13335","type":"journal-article","created":{"date-parts":[[2017,6,21]],"date-time":"2017-06-21T10:50:01Z","timestamp":1498042201000},"page":"1062-1070","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["The spectrum of aseptic central nervous system infections in southern Germany \u2013 demographic, clinical and laboratory findings"],"prefix":"10.1111","volume":"24","author":[{"given":"M.","family":"Kaminski","sequence":"first","affiliation":[{"name":"Department of Neurology Klinikum rechts der Isar Technical University of Munich Munich 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