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A comprehensive literature search of the PubMed, Embase, MEDLINE and Cochrane Library databases for relevant observational studies (cohort\/case\u2212control) from March 1984 to March 2016 was undertaken. Two review authors independently examined the full text records to determine which studies met the inclusion criteria and evaluated risk factors for <jats:styled-content style=\"fixed-case\">PAIS<\/jats:styled-content>. Risk ratios, odds ratios and 95% confidence intervals were estimated. A total of 11 studies were included in the analyses. Intrapartum fever &gt;38\u00b0C, pre\u2010eclampsia, oligohydramnios, primiparity, forceps delivery, vacuum delivery, fetal heart rate abnormalities, abnormal cardiotocography tracing, cord abnormalities, birth asphyxia, emergency caesarean section, tight nuchal cord, meconium\u2010stained amniotic fluid, umbilical arterial <jats:styled-content style=\"fixed-case\">pH<\/jats:styled-content> &lt;7.10, Apgar score at 5 min &lt;7, resuscitation at birth, hypoglycaemia, male gender and small for gestational age were identified as risk factors for <jats:styled-content style=\"fixed-case\">PAIS<\/jats:styled-content>. This systemic review and meta\u2010analysis provides a preliminary evidence\u2010based assessment of the risk factors for <jats:styled-content style=\"fixed-case\">PAIS<\/jats:styled-content>. Patients with any of the risk factors identified in this analysis should be given careful consideration to ensure the prevention of <jats:styled-content style=\"fixed-case\">PAIS<\/jats:styled-content>. Future studies focusing on the combined effects of multiple prenatal, perinatal and neonatal risk factors for <jats:styled-content style=\"fixed-case\">PAIS<\/jats:styled-content> are warranted.<\/jats:p>","DOI":"10.1111\/ene.13337","type":"journal-article","created":{"date-parts":[[2017,6,24]],"date-time":"2017-06-24T06:24:37Z","timestamp":1498285477000},"page":"1006-1015","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":65,"title":["Prenatal, perinatal and neonatal risk factors for perinatal arterial ischaemic stroke: a systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"24","author":[{"given":"C.","family":"Li","sequence":"first","affiliation":[{"name":"Department of Neonatology Ministry of Education Key Laboratory of Child Development and Disorders Children's Hospital of Chongqing Medical University Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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