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In the present study, <jats:styled-content style=\"fixed-case\">BBB<\/jats:styled-content> permeability during spontaneous attacks of migraine without aura was investigated compared to an interictal state.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Seventy\u2010four patients suffering from migraine without aura were recruited to participate in this cross\u2010sectional dynamic contrast\u2010enhanced magnetic resonance imaging (<jats:styled-content style=\"fixed-case\">DCE<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>) study. The patients were instructed to report at the hospital for <jats:styled-content style=\"fixed-case\">DCE<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> scan during and outside of a spontaneous migraine attack. The primary end\u2010point was a difference in the <jats:styled-content style=\"fixed-case\">BBB<\/jats:styled-content> permeability (<jats:styled-content style=\"fixed-case\">ml<\/jats:styled-content>\/100 g\/min) between the attack and the headache\u2010free days. The permeability was assessed in five different regions of interest (<jats:styled-content style=\"fixed-case\">ROI<\/jats:styled-content>s) located in the anterior, middle and posterior cerebral area, brain stem, posterior pons and whole brain. The paired samples <jats:italic>t<\/jats:italic> test was used to compare <jats:italic>K<\/jats:italic><jats:sub>i<\/jats:sub> (permeability) values between the attack and headache\u2010free days.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Nineteen patients completed the study. Median time from onset of migraine attack to scan was 6.5 h (range 4.0\u201315.5 h). No change in the mean <jats:styled-content style=\"fixed-case\">BBB<\/jats:styled-content> permeability (<jats:styled-content style=\"fixed-case\">ml<\/jats:styled-content>\/100 g\/min) was found between the attack and the headache\u2010free days in any of the measured <jats:styled-content style=\"fixed-case\">ROI<\/jats:styled-content>s. No relationship between the pain side or intensity and <jats:styled-content style=\"fixed-case\">BBB<\/jats:styled-content> permeability was found in 15 patients with unilateral pain during the examined attack.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>It was demonstrated that the <jats:styled-content style=\"fixed-case\">BBB<\/jats:styled-content> permeability during spontaneous migraine attacks without aura was unchanged.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.13341","type":"journal-article","created":{"date-parts":[[2017,7,20]],"date-time":"2017-07-20T09:37:21Z","timestamp":1500543441000},"page":"1116-1124","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":69,"title":["Intact blood\u2212brain barrier during spontaneous attacks of migraine without aura: a 3T <scp>DCE<\/scp>\u2010<scp>MRI<\/scp> study"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3803-3599","authenticated-orcid":false,"given":"F. 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