{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T15:48:38Z","timestamp":1791388118249,"version":"4.3.3"},"reference-count":39,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2017,7,5]],"date-time":"2017-07-05T00:00:00Z","timestamp":1499212800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002345","name":"Eberhard Karls Universit\u00e4t T\u00fcbingen","doi-asserted-by":"publisher","award":["386\u20100\u20100"],"award-info":[{"award-number":["386\u20100\u20100"]}],"id":[{"id":"10.13039\/501100002345","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>High\u2010resolution ultrasound is a valuable tool in supporting the diagnosis of multifocal motor neuropathy (<jats:styled-content style=\"fixed-case\">MMN<\/jats:styled-content>) but longitudinal data under therapy are lacking.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The change in peripheral nerve ultrasound pattern in patients with <jats:styled-content style=\"fixed-case\">MMN<\/jats:styled-content> was assessed over time. Patients with <jats:styled-content style=\"fixed-case\">MMN<\/jats:styled-content> received a thorough initial examination and follow\u2010up over a period of 6\u201312\u00a0months using high\u2010resolution ultrasound of the cervical roots and the nerves of the arms and legs, nerve conduction studies, Medical Research Council Sum Score (<jats:styled-content style=\"fixed-case\">MRCSS<\/jats:styled-content>) and <jats:styled-content style=\"fixed-case\">Rotterdam Inflammatory Neuropathy Cause and Treatment Group (INCAT<\/jats:styled-content>) score to evaluate changes under treatment. The Ultrasound Pattern Sum Score (<jats:styled-content style=\"fixed-case\">UPSS<\/jats:styled-content>) was used as standardized peripheral nerve ultrasound protocol.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seventeen patients with <jats:styled-content style=\"fixed-case\">MMN<\/jats:styled-content> received initial examinations of whom 12 were successfully followed up. All patients with <jats:styled-content style=\"fixed-case\">MMN<\/jats:styled-content> showed at least localized but often multifocal peripheral nerve enlargement. An enlarged overall cross\u2010sectional area as well as enlarged single fascicles (&gt;3\u00a0mm\u00b2) in clinically and electrophysiologically affected (&gt;90%) and unaffected (&gt;70%) nerves were found. The <jats:styled-content style=\"fixed-case\">UPSS<\/jats:styled-content> did not correlate with clinical disability at both visits. However, the change in clinical disability (evaluated as difference in <jats:styled-content style=\"fixed-case\">MRCSS<\/jats:styled-content>) and the change in <jats:styled-content style=\"fixed-case\">UPSS<\/jats:styled-content> correlated significantly inversely (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.004).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>High\u2010resolution sonography of peripheral nerves revealed multifocal nerve enlargement in <jats:styled-content style=\"fixed-case\">MMN<\/jats:styled-content>. Distinct enlargement patterns may support the diagnosis. Ultrasound findings did not correlate well with clinical severity or electrophysiological findings at initial presentation. As changes in <jats:styled-content style=\"fixed-case\">UPSS<\/jats:styled-content> correlated significantly with the clinical course in terms of muscle strength (<jats:styled-content style=\"fixed-case\">MRCSS<\/jats:styled-content>), sonographic assessment may represent a useful tool for therapeutic monitoring.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.13344","type":"journal-article","created":{"date-parts":[[2017,7,6]],"date-time":"2017-07-06T04:43:35Z","timestamp":1499316215000},"page":"1125-1134","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["Nerve ultrasound as follow\u2010up tool in treated multifocal motor neuropathy"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5456-7761","authenticated-orcid":false,"given":"T. W.","family":"Rattay","sequence":"first","affiliation":[{"name":"Department of Neurology T\u00fcbingen University Hospital T\u00fcbingen Germany"},{"name":"Hertie Institute for Clinical Brain Research and German Center of Neurodegenerative Diseases (DZNE) University of T\u00fcbingen T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Winter","sequence":"additional","affiliation":[{"name":"Department of Neurology T\u00fcbingen University Hospital T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. F.","family":"D\u00e9card","sequence":"additional","affiliation":[{"name":"Department of Neurology Basel University Hospital Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. M.","family":"Dammeier","sequence":"additional","affiliation":[{"name":"Department of Neurology T\u00fcbingen University Hospital T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"H\u00e4rtig","sequence":"additional","affiliation":[{"name":"Department of Neurology T\u00fcbingen University Hospital T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Ceanga","sequence":"additional","affiliation":[{"name":"Hans Berger Department of Neurology Jena University Hospital Jena Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Axer","sequence":"additional","affiliation":[{"name":"Hans Berger Department of Neurology Jena University Hospital Jena Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Grimm","sequence":"additional","affiliation":[{"name":"Department of Neurology T\u00fcbingen University Hospital T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,7,5]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"167","article-title":"Pure motor neuropathy with multifocal conduction block masquerading as motor neuron disease","volume":"8","author":"Parry G","year":"1985","journal-title":"Muscle Nerve"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000116045"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.36.9.1260"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410240113"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000282734"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181f0738e"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2011.175"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-010-9408-3"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2006.01466.x"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880160606"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880170114"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00296548"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2010.205856"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410280312"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.25138"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-015-7953-7"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-016-8100-9"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.48.5.1218"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2008.05.004"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2008.01.101"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-013-7123-8"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2015.01.011"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2013.07.023"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.24227"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.23252"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000169179.67764.30"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.12182"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-015-7648-0"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-015-7927-9"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.10410"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.54.4.943"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2005.076174"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880141111"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.7754\/Clin.Lab.2013.121116"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-016-8305-y"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000001291"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.10454"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000000128"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000003483"}],"container-title":["European Journal of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fene.13344","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ene.13344","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T16:21:53Z","timestamp":1695572513000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ene.13344"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7,5]]},"references-count":39,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2017,9]]}},"alternative-id":["10.1111\/ene.13344"],"URL":"https:\/\/doi.org\/10.1111\/ene.13344","archive":["Portico"],"relation":{},"ISSN":["1351-5101","1468-1331"],"issn-type":[{"value":"1351-5101","type":"print"},{"value":"1468-1331","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,7,5]]},"assertion":[{"value":"2017-03-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-05-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-07-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}