{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,22]],"date-time":"2026-02-22T02:58:02Z","timestamp":1771729082478,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2017,7,14]],"date-time":"2017-07-14T00:00:00Z","timestamp":1499990400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003621","name":"Ministry of Science, ICT and Future Planning","doi-asserted-by":"publisher","award":["2016M3C7A1914002"],"award-info":[{"award-number":["2016M3C7A1914002"]}],"id":[{"id":"10.13039\/501100003621","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>Although a stroke from atherosclerosis in the basilar artery (<jats:styled-content style=\"fixed-case\">BA<\/jats:styled-content>) often presents with mild initial stroke severity, it has heterogeneous clinical courses. We investigated the efficacy of digital subtraction angiography (<jats:styled-content style=\"fixed-case\">DSA<\/jats:styled-content>)\u2010based collateral perfusion evaluation in association with long\u2010term outcomes of medically treated symptomatic basilar artery stenosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>From a registry database of all consecutive patients with stroke, we included 98 medically treated patients (due to mild initial stroke severity) [National Institute of Health Stroke Scale (<jats:styled-content style=\"fixed-case\">NIHSS<\/jats:styled-content>) scores \u2264 4; symptomatic basilar artery stenosis, 70\u201399%] with available initial diagnostic <jats:styled-content style=\"fixed-case\">DSA<\/jats:styled-content>. Basilar collateral scoring was performed via the <jats:styled-content style=\"fixed-case\">DSA<\/jats:styled-content>, using a modified version of the American Society of Interventional and Therapeutic Neuroradiology\/Society of Interventional Radiology grading system in both the superior cerebellar artery and anterior\/posterior\u2010inferior cerebellar artery territories (score 0\u20138). The outcomes were designated as the 90\u2010day modified Rankin Scale (<jats:styled-content style=\"fixed-case\">mRS<\/jats:styled-content>90) score (poor, 3\u20136). Student's <jats:italic>t<\/jats:italic>\u2010test, chi\u2010square test and logistic regression analyses were used to identify factors associated with a poor outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median initial <jats:styled-content style=\"fixed-case\">NIHSS<\/jats:styled-content> score was 2 [interquartile range (<jats:styled-content style=\"fixed-case\">IQR)<\/jats:styled-content>, 0\u20133], median posterior circulation Alberta Stroke Program Early <jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> Score was 8 (IQR, 7\u201310), median collateral score was 7 (IQR, 7\u20138) and 20 (20.4%) had poor <jats:styled-content style=\"fixed-case\">mRS<\/jats:styled-content>90 scores. In multivariate analysis, poorer collateral scores (<jats:italic>P<\/jats:italic> = 0.003), higher <jats:styled-content style=\"fixed-case\">NIHSS<\/jats:styled-content> scores (<jats:italic>P<\/jats:italic> = 0.005) and lower posterior circulation Alberta Stroke Program Early <jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> Score (<jats:italic>P<\/jats:italic> = 0.017) were independently associated with a poor <jats:styled-content style=\"fixed-case\">mRS<\/jats:styled-content>90 score.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">The DSA<\/jats:styled-content>\u2010based collateral scoring of the <jats:styled-content style=\"fixed-case\">BA<\/jats:styled-content> large branches might predict long\u2010term outcome in medically treated symptomatic basilar artery stenosis with mild initial severity. Evaluation of <jats:styled-content style=\"fixed-case\">BA<\/jats:styled-content> collateral perfusion status might be useful to determine appropriate treatment strategies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.13351","type":"journal-article","created":{"date-parts":[[2017,7,14]],"date-time":"2017-07-14T06:29:02Z","timestamp":1500013742000},"page":"1148-1155","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Utility of digital subtraction angiography\u2010based collateral evaluation in medically treated acute symptomatic basilar artery stenosis"],"prefix":"10.1111","volume":"24","author":[{"given":"W.\u2010J.","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Neurology Seoul National University Hospital Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1433-8005","authenticated-orcid":false,"given":"K.\u2010H.","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Neurology Seoul National University Hospital Seoul South Korea"},{"name":"Program in Neuroscience Neuroscience Research Institute of SNUMRC College of Medicine Seoul National University Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y. J.","family":"Ryu","sequence":"additional","affiliation":[{"name":"Department of Radiology Seoul National University Hospital Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.\u2010M.","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurology Chung\u2010Ang University Hospital Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.\u2010T.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Neurology Seoul National University Hospital Seoul South Korea"},{"name":"Program in Neuroscience Neuroscience Research Institute of SNUMRC College of Medicine Seoul National University Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Chu","sequence":"additional","affiliation":[{"name":"Department of Neurology Seoul National University Hospital Seoul South Korea"},{"name":"Program in Neuroscience Neuroscience Research Institute of SNUMRC College of Medicine Seoul National University Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurology Seoul National University Hospital Seoul South Korea"},{"name":"Program in Neuroscience Neuroscience Research Institute of SNUMRC College of Medicine Seoul National University Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. 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