{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T11:30:56Z","timestamp":1790767856138,"version":"4.1.0"},"reference-count":18,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2017,7,20]],"date-time":"2017-07-20T00:00:00Z","timestamp":1500508800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Minist\u00e8re charg\u00e9 de l'agriculture et du d\u00e9veloppement"},{"name":"Office national de l'eau et des milieux aquatiques"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>The association of farming with motor neuron disease (<jats:styled-content style=\"fixed-case\">MND<\/jats:styled-content>) is unclear, with conflicting studies. We performed a French nationwide study of the association of farming with <jats:styled-content style=\"fixed-case\">MND<\/jats:styled-content> incidence, and compared findings with those for Parkinson's disease (<jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>), which has been shown to be more frequent in farmers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We used the French national health insurance and hospital discharge databases to identify <jats:styled-content style=\"fixed-case\">MND<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> incident cases. The Mutualit\u00e9 Sociale Agricole (<jats:styled-content style=\"fixed-case\">MSA<\/jats:styled-content>) guarantees health insurance for farmers and agricultural workers. We compared the incidence of <jats:styled-content style=\"fixed-case\">MND<\/jats:styled-content> (2010\u20132014) and <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> (2011\u20132012) in <jats:styled-content style=\"fixed-case\">MSA<\/jats:styled-content> farmers, <jats:styled-content style=\"fixed-case\">MSA<\/jats:styled-content> workers and non\u2010<jats:styled-content style=\"fixed-case\">MSA<\/jats:styled-content> affiliates, and estimated relative risks (<jats:styled-content style=\"fixed-case\">RRs<\/jats:styled-content>) and 95% confidence intervals (<jats:styled-content style=\"fixed-case\">CIs<\/jats:styled-content>). Probabilistic sensitivity analyses were used for external smoking adjustment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Analyses relied on 8931 <jats:styled-content style=\"fixed-case\">MND<\/jats:styled-content> (MSA, 9%) and 45\u00a0409 <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">MSA,<\/jats:styled-content>11%) cases. There was a trend towards higher <jats:styled-content style=\"fixed-case\">MND<\/jats:styled-content> incidence in <jats:styled-content style=\"fixed-case\">MSA<\/jats:styled-content> farmers compared with non\u2010<jats:styled-content style=\"fixed-case\">MSA<\/jats:styled-content> affiliates (<jats:styled-content style=\"fixed-case\">RR,<\/jats:styled-content>1.08; 95% <jats:styled-content style=\"fixed-case\">CI,<\/jats:styled-content>0.99\u20131.18) and <jats:styled-content style=\"fixed-case\">MSA<\/jats:styled-content> workers (<jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content>, 1.13; 95% CI, 0.97\u20131.31) that strengthened after smoking adjustment (if associated with <jats:styled-content style=\"fixed-case\">MND<\/jats:styled-content>). <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> incidence was higher in <jats:styled-content style=\"fixed-case\">MSA<\/jats:styled-content> farmers than non\u2010<jats:styled-content style=\"fixed-case\">MSA<\/jats:styled-content> affiliates (<jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content>, 1.13; 95% CI, 1.08\u20131.17) and <jats:styled-content style=\"fixed-case\">MSA<\/jats:styled-content> workers (<jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content>, 1.10; 95% CI, 1.02\u20131.18); this association remained after smoking adjustment (<jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content>, 1.09; 95% CI, 1.05\u20131.14).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This French nationwide study suggested an association between farming and <jats:styled-content style=\"fixed-case\">MND<\/jats:styled-content>, and confirmed higher <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> incidence in farmers in France, a country with high pesticide use.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.13353","type":"journal-article","created":{"date-parts":[[2017,7,20]],"date-time":"2017-07-20T09:48:47Z","timestamp":1500544127000},"page":"1191-1195","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Farming and incidence of motor neuron disease: French nationwide study"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6041-9602","authenticated-orcid":false,"given":"S.","family":"Kab","sequence":"first","affiliation":[{"name":"Sant\u00e9 publique France Saint\u2010Maurice"},{"name":"Universit\u00e9 Paris\u2010Sud UVSQ CESP INSERM, Universit\u00e9 Paris\u2010Saclay Villejuif France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7063-9550","authenticated-orcid":false,"given":"F.","family":"Moisan","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris\u2010Sud UVSQ CESP 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