{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:49:20Z","timestamp":1787014160215,"version":"build-2736575974"},"reference-count":15,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2017,7,14]],"date-time":"2017-07-14T00:00:00Z","timestamp":1499990400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Brain Foundation Netherlands","award":["HA2015.01.05"],"award-info":[{"award-number":["HA2015.01.05"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background and purpose<\/jats:title>\n                    <jats:p>\n                      Infection with the John Cunningham virus (\n                      <jats:styled-content style=\"fixed-case\">JCV<\/jats:styled-content>\n                      ) is required for the development of progressive multifocal leukoencephalopathy, the feared complication of natalizumab treatment in multiple sclerosis patients. The\n                      <jats:styled-content style=\"fixed-case\">JCV<\/jats:styled-content>\n                      seroconversion rate seems higher in natalizumab treated patients than in the normal population, with an unknown cause.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Natalizumab concentration was correlated to\n                      <jats:styled-content style=\"fixed-case\">JCV<\/jats:styled-content>\n                      antibody status and seroconversion in a large cohort of multiple sclerosis patients.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      One hundred and thirty\u2010five patients were included. No correlation was found between natalizumab concentration and\n                      <jats:styled-content style=\"fixed-case\">JCV<\/jats:styled-content>\n                      status,\n                      <jats:styled-content style=\"fixed-case\">JCV<\/jats:styled-content>\n                      seroconversion or\n                      <jats:styled-content style=\"fixed-case\">JCV<\/jats:styled-content>\n                      index.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Higher natalizumab concentrations do not explain the increased\n                      <jats:styled-content style=\"fixed-case\">JCV<\/jats:styled-content>\n                      seroconversion rate in natalizumab treated patients.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ene.13355","type":"journal-article","created":{"date-parts":[[2017,7,14]],"date-time":"2017-07-14T06:36:46Z","timestamp":1500014206000},"page":"1196-1199","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["John Cunningham virus conversion in relation to natalizumab concentration in multiple sclerosis patients"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9557-5381","authenticated-orcid":false,"given":"Z. L. E.","family":"van Kempen","sequence":"first","affiliation":[{"name":"Department of Neurology Amsterdam Neuroscience VUmc MS Center Amsterdam VU University Medical Center Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. E.","family":"Leurs","sequence":"additional","affiliation":[{"name":"Department of Neurology Amsterdam Neuroscience VUmc MS Center Amsterdam VU University Medical Center Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"de Vries","sequence":"additional","affiliation":[{"name":"Biologicals Lab Sanquin Diagnostic Services, Sanquin Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Vennegoor","sequence":"additional","affiliation":[{"name":"Department of Neurology Amsterdam Neuroscience VUmc MS Center Amsterdam VU University Medical Center Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Rispens","sequence":"additional","affiliation":[{"name":"Department of Immunology Sanquin Research and Landsteiner Laboratory Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. P.","family":"Wattjes","sequence":"additional","affiliation":[{"name":"Department of Radiology &amp; Nuclear Medicine VUmc MS Center Amsterdam VU University Medical Center Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Killestein","sequence":"additional","affiliation":[{"name":"Department of Neurology Amsterdam Neuroscience VUmc MS Center Amsterdam VU University Medical Center Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,7,14]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1107829"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2015-312940"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/1352458516684023"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/apm.12128"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22606"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-012-6487-5"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.12204"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/1352458513505353"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24286"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2012-304332"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.12988"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1212\/NXI.0000000000000195"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2013.02.002"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/1352458517708464"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ab.2011.01.001"}],"container-title":["European Journal of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fene.13355","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ene.13355","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T12:22:18Z","timestamp":1695558138000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ene.13355"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7,14]]},"references-count":15,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2017,9]]}},"alternative-id":["10.1111\/ene.13355"],"URL":"https:\/\/doi.org\/10.1111\/ene.13355","archive":["Portico"],"relation":{},"ISSN":["1351-5101","1468-1331"],"issn-type":[{"value":"1351-5101","type":"print"},{"value":"1468-1331","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,7,14]]},"assertion":[{"value":"2017-01-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-06-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-07-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}