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The incidence of <jats:styled-content style=\"fixed-case\">TBE<\/jats:styled-content> in Europe is increasing due to an extended season of the infection and the enlargement of endemic areas. Our objectives are to provide recommendations on the prevention, diagnosis and management of <jats:styled-content style=\"fixed-case\">TBE<\/jats:styled-content>, based on evidence or consensus decisions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>For systematic evaluation, the literature was searched from 1970 to 2015 (including early online publications of 2016), and recommendations were based on evidence or consensus decisions of the Task Force when evidence\u2010based data were not available.<\/jats:p><\/jats:sec><jats:sec><jats:title>Recommendations<\/jats:title><jats:p>Vaccination against <jats:styled-content style=\"fixed-case\">TBE<\/jats:styled-content> is recommended for all age groups above 1 year in highly endemic areas (\u22655 cases\/100 000\/year), but also for individuals at risk in areas with a lower incidence. Travellers to endemic areas should be vaccinated if their visits will include extensive outdoor activities. Post\u2010exposure prophylaxis after a tick bite is not recommended. A case of <jats:styled-content style=\"fixed-case\">TBE<\/jats:styled-content> is defined by the presence of clinical signs of meningitis, meningoencephalitis or meningoencephalomyelitis with cerebrospinal fluid (<jats:styled-content style=\"fixed-case\">CSF<\/jats:styled-content>) pleocytosis (&gt;5 \u00d7 10<jats:sup>6<\/jats:sup> cells\/l) and the presence of specific <jats:styled-content style=\"fixed-case\">TBEV<\/jats:styled-content> serum immunoglobulin M (IgM) and IgG antibodies, <jats:styled-content style=\"fixed-case\">CSF<\/jats:styled-content> IgM antibodies or <jats:styled-content style=\"fixed-case\">TBEV<\/jats:styled-content> IgG seroconversion. <jats:styled-content style=\"fixed-case\">TBEV<\/jats:styled-content>\u2010specific polymerase chain reaction in blood is diagnostic in the first viremic phase but it is not sensitive in the second phase of <jats:styled-content style=\"fixed-case\">TBE<\/jats:styled-content> with clinical manifestations of <jats:styled-content style=\"fixed-case\">CNS<\/jats:styled-content> inflammation. Lumbar puncture should be performed in all patients with suspected <jats:styled-content style=\"fixed-case\">CNS<\/jats:styled-content> infection unless there are contraindications. Imaging of the brain and spinal cord has a low sensitivity and a low specificity, but it is useful for differential diagnosis. No effective antiviral or immunomodulating therapy is available for <jats:styled-content style=\"fixed-case\">TBE<\/jats:styled-content>; therefore the treatment is symptomatic. Patients with a potentially life threatening meningoencephalitis or meningoencephalomyelitis should be admitted to an intensive care unit. In the case of brain oedema, analgosedation should be deepened; osmotherapy and corticosteroids are not routinely recommended. If intracranial pressure is increased, therapeutic hypothermia or decompressive craniectomy might be considered. Seizures should be treated as any other symptomatic epileptic seizures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Tick\u2010borne encephalitis is a viral <jats:styled-content style=\"fixed-case\">CNS<\/jats:styled-content> infection that may result in long\u2010term neurological sequelae. Since its incidence in Europe is increasing due to broadening of endemic areas and prolongation of the tick activity season, the health burden of <jats:styled-content style=\"fixed-case\">TBE<\/jats:styled-content> is enlarging. There is no effective antiviral treatment for <jats:styled-content style=\"fixed-case\">TBE<\/jats:styled-content>, but the disease may be effectively prevented by vaccination.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.13356","type":"journal-article","created":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T11:04:43Z","timestamp":1501585483000},"page":"1214","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":207,"title":["EAN consensus review on prevention, diagnosis and management of tick\u2010borne encephalitis"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5439-1022","authenticated-orcid":false,"given":"P.","family":"Taba","sequence":"first","affiliation":[{"name":"Department of Neurology and Neurosurgery University of Tartu Tartu 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